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Tal1 T cell acute lymphocytic leukemia 1 [ Mus musculus (house mouse) ]

Gene ID: 21349, updated on 5-Jan-2023

Summary

Official Symbol
Tal1provided by MGI
Official Full Name
T cell acute lymphocytic leukemia 1provided by MGI
Primary source
MGI:MGI:98480
See related
Ensembl:ENSMUSG00000028717 AllianceGenome:MGI:98480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hpt; Scl; tal-1; bHLHa17; SCL/tal-1
Summary
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA binding activity. Involved in embryonic hemopoiesis; positive regulation of erythrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; hemolymphoid system; and sensory organ. Used to study lymphoid leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 43.3), liver E14 (RPKM 39.2) and 8 other tissues See more
Orthologs
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Genomic context

See Tal1 in Genome Data Viewer
Location:
4 D1; 4 52.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114913623..114928952)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115056426..115071755)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Scl/Tal1 interrupting locus Neighboring gene predicted gene, 52674 Neighboring gene predicted gene, 33786 Neighboring gene PDZK1 interacting protein 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within astrocyte fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect erythrocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within generation of neurons IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemangioblast cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within platelet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mast cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within spinal cord association neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_positive_effect transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell acute lymphocytic leukemia protein 1 homolog
Names
stem cell protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287388.1NP_001274317.1  T-cell acute lymphocytic leukemia protein 1 homolog

    See identical proteins and their annotated locations for NP_001274317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK157852, BC063060
    Consensus CDS
    CCDS18486.1
    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Related
    ENSMUSP00000125202.2, ENSMUST00000161601.8
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  2. NM_011527.3NP_035657.1  T-cell acute lymphocytic leukemia protein 1 homolog

    See identical proteins and their annotated locations for NP_035657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    BC063060
    Consensus CDS
    CCDS18486.1
    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Related
    ENSMUSP00000030489.3, ENSMUST00000030489.9
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    114913623..114928952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502912.5XP_006502975.1  T-cell acute lymphocytic leukemia protein 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006502975.1

    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Related
    ENSMUSP00000124983.2, ENSMUST00000162489.2
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  2. XM_006502916.4XP_006502979.1  T-cell acute lymphocytic leukemia protein 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006502979.1

    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  3. XM_006502910.4XP_006502973.1  T-cell acute lymphocytic leukemia protein 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006502973.1

    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  4. XM_006502914.5XP_006502977.1  T-cell acute lymphocytic leukemia protein 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006502977.1

    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  5. XM_030253382.2XP_030109242.1  T-cell acute lymphocytic leukemia protein 1 homolog isoform X2

    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  6. XM_006502913.5XP_006502976.1  T-cell acute lymphocytic leukemia protein 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006502976.1

    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  7. XM_006502915.3XP_006502978.1  T-cell acute lymphocytic leukemia protein 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006502978.1

    UniProtKB/Swiss-Prot
    P22091
    UniProtKB/TrEMBL
    A0A8C6ING3, Q3TZH7
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  8. XM_006502909.3XP_006502972.1  T-cell acute lymphocytic leukemia protein 1 homolog isoform X1

    Conserved Domains (1) summary
    cd19706
    Location:191255
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins