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Tifab TRAF-interacting protein with forkhead-associated domain, family member B [ Mus musculus (house mouse) ]

Gene ID: 212937, updated on 5-Mar-2024

Summary

Official Symbol
Tifabprovided by MGI
Official Full Name
TRAF-interacting protein with forkhead-associated domain, family member Bprovided by MGI
Primary source
MGI:MGI:2385852
See related
Ensembl:ENSMUSG00000049625 AllianceGenome:MGI:2385852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in several processes, including animal organ morphogenesis; cranial nerve development; and hard palate morphogenesis. Orthologous to human TIFAB (TIFA inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 9.0), lung adult (RPKM 4.1) and 21 other tissues See more
Orthologs
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Genomic context

Location:
13 B1; 13 30.06 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (56318917..56326816, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (56173703..56179002, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene macroH2A.1 histone Neighboring gene STARR-seq mESC enhancer starr_34633 Neighboring gene predicted gene, 31485 Neighboring gene STARR-seq mESC enhancer starr_34635 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:56277360-56277561 Neighboring gene predicted gene, 31657 Neighboring gene predicted gene, 25148 Neighboring gene STARR-seq mESC enhancer starr_34636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:56298990-56299177 Neighboring gene RIKEN cDNA 4930550C17 gene Neighboring gene neurogenin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Clone Names

  • MGC32345, MGC37193

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables deubiquitinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in auditory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in cochlea development ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in craniofacial suture morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in genitalia development ISO
Inferred from Sequence Orthology
more info
 
involved_in genitalia morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in hard palate morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in learned vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mastication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of relaxation of muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of saliva secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
involved_in peristalsis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of muscle organ development ISO
Inferred from Sequence Orthology
more info
 
involved_in thorax and anterior abdomen determination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trigeminal nerve development ISO
Inferred from Sequence Orthology
more info
 
involved_in vestibulocochlear nerve formation ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TRAF-interacting protein with FHA domain-containing protein B
Names
TIFA like protein
TIFA related protein TIFAB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168615.1NP_001162086.1  TRAF-interacting protein with FHA domain-containing protein B

    See identical proteins and their annotated locations for NP_001162086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124395, AK153654, BY209244
    Consensus CDS
    CCDS26558.1
    UniProtKB/Swiss-Prot
    Q05DP7, Q571I3, Q8JZM6
    Related
    ENSMUSP00000152976.2, ENSMUST00000225063.2
    Conserved Domains (1) summary
    pfam00498
    Location:37107
    FHA; FHA domain
  2. NM_145976.4NP_666088.1  TRAF-interacting protein with FHA domain-containing protein B

    See identical proteins and their annotated locations for NP_666088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124395, AK036643, BY209244
    Consensus CDS
    CCDS26558.1
    UniProtKB/Swiss-Prot
    Q05DP7, Q571I3, Q8JZM6
    Related
    ENSMUSP00000131162.2, ENSMUST00000169652.3
    Conserved Domains (1) summary
    pfam00498
    Location:37107
    FHA; FHA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    56318917..56326816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517204.5XP_006517267.1  TRAF-interacting protein with FHA domain-containing protein B isoform X1

    See identical proteins and their annotated locations for XP_006517267.1

    UniProtKB/Swiss-Prot
    Q05DP7, Q571I3, Q8JZM6
    Conserved Domains (1) summary
    pfam00498
    Location:37107
    FHA; FHA domain