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TIFAB TIFA inhibitor [ Homo sapiens (human) ]

Gene ID: 497189, updated on 5-Aug-2022

Summary

Official Symbol
TIFABprovided by HGNC
Official Full Name
TIFA inhibitorprovided by HGNC
Primary source
HGNC:HGNC:34024
See related
Ensembl:ENSG00000255833 MIM:612663; AllianceGenome:HGNC:34024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]
Expression
Biased expression in lymph node (RPKM 4.5), appendix (RPKM 3.4) and 12 other tissues See more
Orthologs
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Genomic context

See TIFAB in Genome Data Viewer
Location:
5q31.1
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135444226..135452351, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (135971397..135979522, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134779916..134788041, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PITX1 antisense RNA 1 Neighboring gene macroH2A.1 histone Neighboring gene VISTA enhancer hs1473 Neighboring gene uncharacterized LOC124901073 Neighboring gene dendritic cell associated nuclear protein 1 Neighboring gene Sharpr-MPRA regulatory region 2127 Neighboring gene Sharpr-MPRA regulatory region 242 Neighboring gene neurogenin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Potential readthrough

Included gene: DCANP1

Homology

Clone Names

  • FLJ00292

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in auditory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cochlea development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in craniofacial suture morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in genitalia development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in genitalia morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hard palate morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inner ear development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in learned vocalization behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mastication IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of relaxation of muscle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of saliva secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peristalsis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of muscle organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in thorax and anterior abdomen determination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in trigeminal nerve development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vestibulocochlear nerve formation IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
TRAF-interacting protein with FHA domain-containing protein B
Names
TIFA-like protein
TIFA-related protein TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099221.2NP_001092691.1  TRAF-interacting protein with FHA domain-containing protein B

    See identical proteins and their annotated locations for NP_001092691.1

    Status: VALIDATED

    Source sequence(s)
    AB161513, AC022092, AK131088, BX119085
    Consensus CDS
    CCDS43365.1
    UniProtKB/Swiss-Prot
    Q5H8A9, Q6ZNK6
    Related
    ENSP00000440509.1, ENST00000537858.2
    Conserved Domains (1) summary
    cd00060
    Location:31117
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    135444226..135452351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    135971397..135979522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)