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Iffo2 intermediate filament family orphan 2 [ Mus musculus (house mouse) ]

Gene ID: 212632, updated on 17-Aug-2024

Summary

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Official Symbol
Iffo2provided by MGI
Official Full Name
intermediate filament family orphan 2provided by MGI
Primary source
MGI:MGI:2140675
See related
Ensembl:ENSMUSG00000041025 AllianceGenome:MGI:2140675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be located in intermediate filament. Is expressed in 4th ventricle; axial skeleton; choroid plexus; lateral ventricle choroid plexus; and rib. Orthologous to human IFFO2 (intermediate filament family orphan 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 4.9), ovary adult (RPKM 4.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Iffo2 in Genome Data Viewer
Location:
4 D3; 4 70.73 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139257859..139347693)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139530548..139620382)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11828 Neighboring gene STARR-seq mESC enhancer starr_11829 Neighboring gene STARR-seq mESC enhancer starr_11830 Neighboring gene ER membrane protein complex subunit 1 Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene nuclear encoded tRNA valine 1 (anticodon AAC) Neighboring gene VISTA enhancer mm1506 Neighboring gene STARR-seq mESC enhancer starr_11836 Neighboring gene STARR-positive B cell enhancer ABC_E6246 Neighboring gene STARR-positive B cell enhancer ABC_E4694 Neighboring gene aldehyde dehydrogenase 4 family, member A1 Neighboring gene microRNA 7020 Neighboring gene taste receptor, type 1, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36549

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intermediate filament family orphan 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205173.2 → NP_001192102.1  intermediate filament family orphan 2 isoform 1

    See identical proteins and their annotated locations for NP_001192102.1

    Status: VALIDATED

    Source sequence(s)
    AL831790, BX000454
    Consensus CDS
    CCDS57308.1
    UniProtKB/Swiss-Prot
    Q8R2V2
    Related
    ENSMUSP00000134062.2, ENSMUST00000174078.2
    Conserved Domains (2) summary
    pfam00038
    Location:189 → 478
    Filament; Intermediate filament protein
    pfam16566
    Location:212 → 259
    CREPT; Cell-cycle alteration and expression-elevated protein in tumour

  2. NM_001425010.1 → NP_001411939.1  intermediate filament family orphan 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL831790, BX000454

  3. NM_183148.4 → NP_898971.1  intermediate filament family orphan 2 isoform 2

    See identical proteins and their annotated locations for NP_898971.1

    Status: VALIDATED

    Source sequence(s)
    AL807833, AL831790, BX000454
    Consensus CDS
    CCDS18847.1
    UniProtKB/TrEMBL
    B1AZL1, J3QJZ1
    Related
    ENSMUSP00000133384.2, ENSMUST00000123827.9
    Conserved Domains (1) summary
    pfam00038
    Location:10 → 253
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    139257859..139347693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253381.2 → XP_030109241.1  intermediate filament family orphan 2 isoform X2

    Conserved Domains (2) summary
    pfam15921
    Location:227 → 426
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00038
    Location:350 → 431
    Filament; Intermediate filament protein

  2. XM_030253380.2 → XP_030109240.1  intermediate filament family orphan 2 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:189 → 478
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2V2.2 GenPept UniProtKB/Swiss-Prot:Q8R2V2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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