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Spice1 spindle and centriole associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 212514, updated on 26-Sep-2022

Summary

Official Symbol
Spice1provided by MGI
Official Full Name
spindle and centriole associated protein 1provided by MGI
Primary source
MGI:MGI:1196252
See related
Ensembl:ENSMUSG00000043065 AllianceGenome:MGI:1196252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc52; D16Ertd480e
Summary
Predicted to be involved in metaphase plate congression; mitotic spindle assembly; and regulation of centriole replication. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centriole; centrosome; and spindle. Is expressed in adenohypophysis; brain ventricular layer; nasal cavity epithelium; testis; and thymus primordium. Orthologous to human SPICE1 (spindle and centriole associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.1), CNS E11.5 (RPKM 5.2) and 27 other tissues See more
Orthologs
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Genomic context

See Spice1 in Genome Data Viewer
Location:
16 B4; 16 28.67 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44167761..44208855)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44347399..44388492)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene upstream transcription factor family member 3 Neighboring gene SID1 transmembrane family, member 1 Neighboring gene cilia and flagella associated protein 44 Neighboring gene Boc Hedgehog-responsive enhancer Neighboring gene biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
spindle and centriole-associated protein 1
Names
coiled-coil domain containing 52
coiled-coil domain-containing protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144550.4NP_653133.3  spindle and centriole-associated protein 1

    See identical proteins and their annotated locations for NP_653133.3

    Status: VALIDATED

    Source sequence(s)
    AK048789, BC052381, BY442821, CX568108
    Consensus CDS
    CCDS37345.1
    UniProtKB/Swiss-Prot
    Q8C804, Q8K3I7
    Related
    ENSMUSP00000058832.7, ENSMUST00000050897.7
    Conserved Domains (1) summary
    pfam15678
    Location:35436
    SPICE; Centriole duplication and mitotic chromosome congression

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    44167761..44208855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316923.1XP_017172412.1  spindle and centriole-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C804, Q8K3I7
    Conserved Domains (1) summary
    pfam15678
    Location:35436
    SPICE; Centriole duplication and mitotic chromosome congression
  2. XM_030249036.2XP_030104896.1  spindle and centriole-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam15678
    Location:1383
    SPICE; Centriole duplication and mitotic chromosome congression

RNA

  1. XR_004939178.1 RNA Sequence

  2. XR_004939177.1 RNA Sequence

  3. XR_384543.5 RNA Sequence