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SPICE1 spindle and centriole associated protein 1 [ Homo sapiens (human) ]

Gene ID: 152185, updated on 5-Jan-2020

Summary

Official Symbol
SPICE1provided by HGNC
Official Full Name
spindle and centriole associated protein 1provided by HGNC
Primary source
HGNC:HGNC:25083
See related
Ensembl:ENSG00000163611 Ensembl:ENSG00000285943 MIM:613447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPICE; CCDC52
Expression
Ubiquitous expression in testis (RPKM 3.6), endometrium (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See SPICE1 in Genome Data Viewer
Location:
3q13.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (113442718..113515156, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113161565..113234034, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 44 Neighboring gene Rab geranylgeranyltransferase subunit beta pseudogene Neighboring gene PHD finger protein 5D pseudogene Neighboring gene CFAP44 antisense RNA 1 Neighboring gene microRNA 8076 Neighboring gene SID1 transmembrane family member 1 Neighboring gene microRNA 4446 Neighboring gene RNA, 7SL, cytoplasmic 767, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CFAP44

Homology

Clone Names

  • FLJ26064, FLJ44949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
spindle and centriole-associated protein 1
Names
coiled-coil domain-containing protein 52

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331078.2NP_001318007.1  spindle and centriole-associated protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC112128
    Consensus CDS
    CCDS2973.1
    UniProtKB/Swiss-Prot
    Q8N0Z3
    Related
    ENSP00000497606.1, ENST00000649772.1
    Conserved Domains (1) summary
    pfam15678
    Location:34434
    SPICE; Centriole duplication and mitotic chromosome congression
  2. NM_001331079.1NP_001318008.1  spindle and centriole-associated protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC112128
  3. NM_144718.4NP_653319.1  spindle and centriole-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_653319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AC112128, AY099107, BP278430, U79249
    Consensus CDS
    CCDS2973.1
    UniProtKB/Swiss-Prot
    Q8N0Z3
    Related
    ENSP00000295872.4, ENST00000295872.8
    Conserved Domains (1) summary
    pfam15678
    Location:34434
    SPICE; Centriole duplication and mitotic chromosome congression

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    113442718..113515156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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