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EVI2A ecotropic viral integration site 2A [ Homo sapiens (human) ]

Gene ID: 2123, updated on 21-Dec-2019

Summary

Official Symbol
EVI2Aprovided by HGNC
Official Full Name
ecotropic viral integration site 2Aprovided by HGNC
Primary source
HGNC:HGNC:3499
See related
Ensembl:ENSG00000126860 MIM:158380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVDA; EVI2; EVI-2A
Expression
Broad expression in brain (RPKM 20.1), appendix (RPKM 18.9) and 18 other tissues See more
Orthologs

Genomic context

See EVI2A in Genome Data Viewer
Location:
17q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (31316410..31321622, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29643428..29648767, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2B Neighboring gene NF1 intron 50 Alu-mediated recombination region Neighboring gene adenylate kinase 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ecotropic viral integration site 2A (EVI2A) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein EVI2A
Names
ecotropic viral integration site 2A protein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003927.3NP_001003927.1  protein EVI2A isoform 1

    See identical proteins and their annotated locations for NP_001003927.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC134669, AK295311, CF135330
    Consensus CDS
    CCDS32608.1
    UniProtKB/Swiss-Prot
    P22794
    Related
    ENSP00000247270.3, ENST00000247270.3
    Conserved Domains (1) summary
    pfam05399
    Location:28254
    EVI2A; Ectropic viral integration site 2A protein (EVI2A)
  2. NM_014210.4NP_055025.2  protein EVI2A isoform 2 precursor

    See identical proteins and their annotated locations for NP_055025.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC134669, AK312348, BC035572, CF135330
    Consensus CDS
    CCDS42293.1
    UniProtKB/Swiss-Prot
    P22794
    Related
    ENSP00000420557.3, ENST00000462804.2
    Conserved Domains (1) summary
    pfam05399
    Location:5231
    EVI2A; Ectropic viral integration site 2A protein (EVI2A)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    31316410..31321622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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