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Wdr25 WD repeat domain 25 [ Mus musculus (house mouse) ]

Gene ID: 212198, updated on 2-Nov-2024

Summary

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Official Symbol
Wdr25provided by MGI
Official Full Name
WD repeat domain 25provided by MGI
Primary source
MGI:MGI:3045255
See related
Ensembl:ENSMUSG00000040877 AllianceGenome:MGI:3045255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B930090D16Rik
Summary
Orthologous to human WDR25 (WD repeat domain 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 3.5), testis adult (RPKM 1.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wdr25 in Genome Data Viewer
Location:
12 F1; 12 59.7 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108860155..108994380)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108894152..109028454)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 47 Neighboring gene predicted gene, 22079 Neighboring gene tryptophanyl-tRNA synthetase1 Neighboring gene STARR-positive B cell enhancer ABC_E5353 Neighboring gene STARR-seq mESC enhancer starr_33252 Neighboring gene STARR-seq mESC enhancer starr_33253 Neighboring gene STARR-seq mESC enhancer starr_33254 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene STARR-seq mESC enhancer starr_33255 Neighboring gene brain-enriched guanylate kinase-associated Neighboring gene predicted gene, 52002 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:110295982-110296239 Neighboring gene STARR-positive B cell enhancer mm9_chr12:110312387-110312688 Neighboring gene STARR-positive B cell enhancer mm9_chr12:110313106-110313407 Neighboring gene macrophage migration inhibitory factor, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177602.3 → NP_808270.2  WD repeat-containing protein 25

    See identical proteins and their annotated locations for NP_808270.2

    Status: VALIDATED

    Source sequence(s)
    AC122811, AC140111
    Consensus CDS
    CCDS49172.1
    UniProtKB/Swiss-Prot
    E9Q349, Q8C4T7
    Related
    ENSMUSP00000129855.2, ENSMUST00000167816.8
    Conserved Domains (2) summary
    cd00200
    Location:230 → 534
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:242 → 281
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    108860155..108994380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515661.4 → XP_006515724.1  WD repeat-containing protein 25 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:240 → 280
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:230 → 358
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_011244056.4 → XP_011242358.1  WD repeat-containing protein 25 isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:240 → 280
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:230 → 360
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006515660.5 → XP_006515723.1  WD repeat-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006515723.1

    UniProtKB/Swiss-Prot
    E9Q349, Q8C4T7
    Conserved Domains (2) summary
    cd00200
    Location:230 → 534
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:242 → 281
    7WD40; WD40 repeat [structural motif]

  4. XM_011244054.4 → XP_011242356.1  WD repeat-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011242356.1

    UniProtKB/Swiss-Prot
    E9Q349, Q8C4T7
    Conserved Domains (2) summary
    cd00200
    Location:230 → 534
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:242 → 281
    7WD40; WD40 repeat [structural motif]

  5. XM_006515657.4 → XP_006515720.1  WD repeat-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006515720.1

    UniProtKB/Swiss-Prot
    E9Q349, Q8C4T7
    Conserved Domains (2) summary
    cd00200
    Location:230 → 534
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:242 → 281
    7WD40; WD40 repeat [structural motif]

  6. XM_006515662.4 → XP_006515725.1  WD repeat-containing protein 25 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:241 → 282
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:228 → 441
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_011244057.4 → XP_011242359.1  WD repeat-containing protein 25 isoform X5

    Conserved Domains (2) summary
    sd00039
    Location:240 → 280
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:230 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_011244055.3 → XP_011242357.1  WD repeat-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011242357.1

    UniProtKB/Swiss-Prot
    E9Q349, Q8C4T7
    Related
    ENSMUSP00000035553.8, ENSMUST00000047115.9
    Conserved Domains (2) summary
    cd00200
    Location:230 → 534
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:242 → 281
    7WD40; WD40 repeat [structural motif]

  9. XM_006515658.4 → XP_006515721.1  WD repeat-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006515721.1

    UniProtKB/Swiss-Prot
    E9Q349, Q8C4T7
    Conserved Domains (2) summary
    cd00200
    Location:230 → 534
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:242 → 281
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_003950025.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q349.1 GenPept UniProtKB/Swiss-Prot:E9Q349

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