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Tsga10 testis specific 10 [ Mus musculus (house mouse) ]

Gene ID: 211484, updated on 2-Nov-2024

Summary

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Official Symbol
Tsga10provided by MGI
Official Full Name
testis specific 10provided by MGI
Primary source
MGI:MGI:2685063
See related
Ensembl:ENSMUSG00000060771 AllianceGenome:MGI:2685063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm217; Mtsga10; 4933432N21Rik
Summary
Predicted to enable structural molecule activity. Acts upstream of or within cell projection assembly. Located in cytoplasm; neuron projection; and sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 26. Orthologous to human TSGA10 (testis specific 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 5.9), CNS E18 (RPKM 1.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Tsga10 in Genome Data Viewer
Location:
1 B; 1 15.88 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37793651..37905507, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37754570..37866426, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin like Neighboring gene RIKEN cDNA 4930470B04 gene Neighboring gene STARR-seq mESC enhancer starr_00681 Neighboring gene STARR-seq mESC enhancer starr_00682 Neighboring gene predicted gene, 39628 Neighboring gene STARR-seq mESC enhancer starr_00684 Neighboring gene STARR-positive B cell enhancer mm9_chr1:37921599-37921900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37922129-37922238 Neighboring gene lipoyltransferase 1 Neighboring gene MIT, microtubule interacting and transport, domain containing 1 Neighboring gene mitochondrial ribosomal protein L30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tsga10 expression correlates with sperm profiles in the adult formalin-exposed mice. Tajaddini Mahani S, et al. Andrologia, 2016 Dec. PMID 26791599
  2. Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice. Luo G, et al. Andrology, 2021 Jan. PMID 32790169
  3. Expression of Tsga10 sperm tail protein in embryogenesis and neural development: from cilium to cell division. Behnam B, et al. Biochem Biophys Res Commun, 2006 Jun 16. PMID 16643851
  4. Tsga10 encodes a 65-kilodalton protein that is processed to the 27-kilodalton fibrous sheath protein. Modarressi MH, et al. Biol Reprod, 2004 Mar. PMID 14585816, Free PMC Article
  5. TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha. Hägele S, et al. FEBS Lett, 2006 Jun 26. PMID 16777103

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice.
    Title: Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice.
  2. This study also shows that Tsga10 expression protects sperm dysfunction in formalin plus manganese-exposed mice resulting in better preservation of spermatozoa and improvement of male fertility.
    Title: Tsga10 expression correlates with sperm profiles in the adult formalin-exposed mice.
  3. Tsga10 expression starts in 4.5-7.5 dpc mouse embryos and continues throughout embryogenesis.
    Title: Expression of Tsga10 sperm tail protein in embryogenesis and neural development: from cilium to cell division.
  4. HIF-1alpha nuclear localization and HIF-1 transcriptional activity were significantly affected by overexpressed TSGA10
    Title: TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha.
  5. Tsga10 plays a role in the sperm tail fibrous sheath.
    Title: Tsga10 encodes a 65-kilodalton protein that is processed to the 27-kilodalton fibrous sheath protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis-specific gene 10 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290720.1 → NP_001277649.1  testis-specific gene 10 protein isoform 2

    See identical proteins and their annotated locations for NP_001277649.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' structure and 3' terminal exon, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC123068, AK030254, AK164954, BX637247
    Consensus CDS
    CCDS69883.1
    UniProtKB/Swiss-Prot
    Q6NY15
    Related
    ENSMUSP00000085391.4, ENSMUST00000088072.10
    Conserved Domains (2) summary
    COG1196
    Location:24 → 580
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:223 → 486
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_001290721.1 → NP_001277650.1  testis-specific gene 10 protein isoform 3

    See identical proteins and their annotated locations for NP_001277650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate 3' structure and 3' terminal exon, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC123068, AK030254, BC053407, BX637247, CJ046680, CK789086
    Consensus CDS
    CCDS78571.1
    UniProtKB/Swiss-Prot
    Q6NY15
    Related
    ENSMUSP00000110552.2, ENSMUST00000114902.8
    Conserved Domains (2) summary
    TIGR02168
    Location:361 → 652
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:223 → 498
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. NM_207228.3 → NP_997111.1  testis-specific gene 10 protein isoform 1

    See identical proteins and their annotated locations for NP_997111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC119189, AC123068, AK030254, BC053407, CJ046680, CK789086
    Consensus CDS
    CCDS14894.1
    UniProtKB/Swiss-Prot
    Q68RJ4, Q6NY15, Q8K3V2
    Related
    ENSMUSP00000048859.9, ENSMUST00000041815.15
    Conserved Domains (1) summary
    cl25732
    Location:223 → 498
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_110976.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has an alternate 3' structure and terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123068, AK030254, BC053407, CJ046680
    Related
    ENSMUST00000151735.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37793651..37905507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495822.4 → XP_006495885.1  testis-specific gene 10 protein isoform X2

    UniProtKB/TrEMBL
    A0A668KLF4
    Conserved Domains (2) summary
    COG1196
    Location:224 → 834
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:423 → 698
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_030252660.2 → XP_030108520.1  testis-specific gene 10 protein isoform X4

    UniProtKB/TrEMBL
    A0A668KLF4
    Conserved Domains (2) summary
    COG1196
    Location:48 → 691
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:423 → 686
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. XM_017319575.2 → XP_017175064.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:140 → 504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:361 → 652
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_017319576.2 → XP_017175065.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:140 → 504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:361 → 652
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_017319574.2 → XP_017175063.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:140 → 504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:361 → 652
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_030252667.1 → XP_030108527.1  testis-specific gene 10 protein isoform X8

    Conserved Domains (2) summary
    TIGR02169
    Location:142 → 417
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam15921
    Location:36 → 599
    CCDC158; Coiled-coil domain-containing protein 158

  7. XM_036163236.1 → XP_036019129.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:140 → 504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:361 → 652
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_011238461.3 → XP_011236763.1  testis-specific gene 10 protein isoform X1

    UniProtKB/TrEMBL
    A0A668KLF4
    Related
    ENSMUSP00000159265.2, ENSMUST00000239367.2
    Conserved Domains (2) summary
    COG1196
    Location:224 → 834
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:423 → 698
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  9. XM_017319571.3 → XP_017175060.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A668KLF4
    Conserved Domains (3) summary
    TIGR01843
    Location:655 → 785
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    COG1196
    Location:48 → 691
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:423 → 686
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  10. XM_006495823.5 → XP_006495886.1  testis-specific gene 10 protein isoform X5

    UniProtKB/TrEMBL
    A0A668KLF4
    Conserved Domains (2) summary
    COG1196
    Location:48 → 691
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:423 → 686
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  11. XM_030252666.1 → XP_030108526.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:140 → 504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:361 → 652
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_036163239.1 → XP_036019132.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:140 → 504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:361 → 652
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  13. XM_017319578.3 → XP_017175067.1  testis-specific gene 10 protein isoform X8

    Conserved Domains (2) summary
    TIGR02169
    Location:142 → 417
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam15921
    Location:36 → 599
    CCDC158; Coiled-coil domain-containing protein 158

  14. XM_030252668.1 → XP_030108528.1  testis-specific gene 10 protein isoform X9

    Conserved Domains (2) summary
    COG1196
    Location:30 → 396
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:223 → 469
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  15. XM_011238463.4 → XP_011236765.1  testis-specific gene 10 protein isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:48 → 667
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:423 → 669
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  16. XM_036163247.1 → XP_036019140.1  testis-specific gene 10 protein isoform X10

    Conserved Domains (2) summary
    COG1196
    Location:41 → 386
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:274 → 517
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  17. XM_017319581.3 → XP_017175070.1  testis-specific gene 10 protein isoform X11

    Conserved Domains (2) summary
    TIGR02168
    Location:142 → 471
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl27037
    Location:50 → 96
    FlaC_arch; Flagella accessory protein C (FlaC)

RNA

  1. XR_865225.3 RNA Sequence

  2. XR_003954349.2 RNA Sequence

  3. XR_001783692.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NY15.1 GenPept UniProtKB/Swiss-Prot:Q6NY15

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