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TSGA10 testis specific 10 [ Homo sapiens (human) ]

Gene ID: 80705, updated on 17-Jun-2019

Summary

Official Symbol
TSGA10provided by HGNC
Official Full Name
testis specific 10provided by HGNC
Primary source
HGNC:HGNC:14927
See related
Ensembl:ENSG00000135951 MIM:607166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT79; CEP4L; SPGF26
Expression
Biased expression in testis (RPKM 16.6) and thyroid (RPKM 1.5) See more
Orthologs

Genomic context

See TSGA10 in Genome Data Viewer
Location:
2q11.2
Exon count:
32
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (98997261..99154966, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99613724..99771187, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 84, pseudogene Neighboring gene KIAA1211 like Neighboring gene RNA, U7 small nuclear 46 pseudogene Neighboring gene structural maintenance of chromosomes 3 pseudogene Neighboring gene chromosome 2 open reading frame 15 Neighboring gene lipoyltransferase 1 Neighboring gene microtubule interacting and trafficking domain containing 1 Neighboring gene mitochondrial ribosomal protein L30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
SPERMATOGENIC FAILURE 26
MedGen: C4693773 OMIM: 617961 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell projection assembly IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
centriole IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
sperm fibrous sheath IEA
Inferred from Electronic Annotation
more info
 
sperm principal piece IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
testis-specific gene 10 protein
Names
cancer/testis antigen 79
testis development protein NYD-SP7
testis-specific 10 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349012.1NP_001335941.1  testis-specific gene 10 protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC019097, AC092587, AC110083
    Consensus CDS
    CCDS2037.1
    Related
    ENSP00000377122.3, ENST00000393482.7
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  2. NM_001349013.2NP_001335942.1  testis-specific gene 10 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks three alternate in-frame exons in the 5' coding region compared to variant 1. Both variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AC019097, AC092587, AC110083
    Conserved Domains (2) summary
    cl25632
    Location:90280
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    cl25732
    Location:214490
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001349014.1NP_001335943.1  testis-specific gene 10 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks three alternate in-frame exons in the 5' coding region compared to variant 1. Both variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AC019097, AC092587
    Conserved Domains (2) summary
    cl25632
    Location:90280
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    cl25732
    Location:214490
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_025244.4NP_079520.1  testis-specific gene 10 protein isoform 1

    See identical proteins and their annotated locations for NP_079520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC019097, AC092587, AF254756, BX647157, DB085678, DC396566
    Consensus CDS
    CCDS2037.1
    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Related
    ENSP00000377123.3, ENST00000393483.8
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  5. NM_182911.4NP_878915.2  testis-specific gene 10 protein isoform 1

    See identical proteins and their annotated locations for NP_878915.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC019097, AC092587, AF254756, BC028366, BI562202
    Consensus CDS
    CCDS2037.1
    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Related
    ENSP00000347161.4, ENST00000355053.8
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)

RNA

  1. NR_146001.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate first exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC019097, AC092587, AC110083
  2. NR_146053.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC092587, BE044403, BX490754
  3. NR_146054.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC092587, BE044403
  4. NR_146055.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC092587, BE044403

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    98997261..99154966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005047.1XP_016860536.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  2. XM_011511937.1XP_011510239.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_011510239.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  3. XM_006712781.2XP_006712844.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_006712844.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  4. XM_017005044.1XP_016860533.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  5. XM_017005040.2XP_016860529.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  6. XM_017005041.2XP_016860530.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  7. XM_017005045.1XP_016860534.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  8. XM_024453160.1XP_024308928.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  9. XM_024453158.1XP_024308926.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  10. XM_017005048.1XP_016860537.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  11. XM_017005042.1XP_016860531.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  12. XM_005264025.2XP_005264082.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_005264082.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  13. XM_024453161.1XP_024308929.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  14. XM_005264026.1XP_005264083.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_005264083.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  15. XM_017005046.1XP_016860535.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  16. XM_005264024.2XP_005264081.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_005264081.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  17. XM_011511939.1XP_011510241.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_011510241.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  18. XM_011511942.1XP_011510244.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_011510244.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  19. XM_011511941.1XP_011510243.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_011510243.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  20. XM_005264027.1XP_005264084.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_005264084.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  21. XM_005264023.1XP_005264080.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_005264080.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  22. XM_017005039.1XP_016860528.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  23. XM_017005035.1XP_016860524.1  testis-specific gene 10 protein isoform X2

  24. XM_011511934.1XP_011510236.1  testis-specific gene 10 protein isoform X1

    Conserved Domains (1) summary
    pfam05377
    Location:5096
    FlaC_arch; Flagella accessory protein C (FlaC)
  25. XM_005264029.1XP_005264086.1  testis-specific gene 10 protein isoform X7

    See identical proteins and their annotated locations for XP_005264086.1

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  26. XM_011511935.3XP_011510237.1  testis-specific gene 10 protein isoform X3

    Conserved Domains (3) summary
    COG1196
    Location:268632
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4372
    Location:540743
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    TIGR02168
    Location:70399
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  27. XM_024453159.1XP_024308927.1  testis-specific gene 10 protein isoform X7

    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  28. XM_017005043.2XP_016860532.1  testis-specific gene 10 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9
    Related
    ENSP00000386956.1, ENST00000410001.5
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  29. XM_017005037.1XP_016860526.1  testis-specific gene 10 protein isoform X5

  30. XM_017005038.1XP_016860527.1  testis-specific gene 10 protein isoform X6

  31. XM_017005036.2XP_016860525.1  testis-specific gene 10 protein isoform X4

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