U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TSGA10 testis specific 10 [ Homo sapiens (human) ]

Gene ID: 80705, updated on 9-Dec-2024

Summary

Official Symbol
TSGA10provided by HGNC
Official Full Name
testis specific 10provided by HGNC
Primary source
HGNC:HGNC:14927
See related
Ensembl:ENSG00000135951 MIM:607166; AllianceGenome:HGNC:14927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT79; CEP4L; SPGF26
Summary
Predicted to enable structural molecule activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within cell projection assembly. Predicted to be located in neuron projection; sperm fibrous sheath; and sperm principal piece. Predicted to be active in motile cilium. Implicated in spermatogenic failure 26. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis (RPKM 16.6) and thyroid (RPKM 1.5) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TSGA10 in Genome Data Viewer
Location:
2q11.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (98997261..99154966, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99455791..99613837, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99613724..99771429, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 84, pseudogene Neighboring gene CRACD like Neighboring gene Sharpr-MPRA regulatory region 14605 Neighboring gene RNA, U7 small nuclear 46 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99485973-99486580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99526123-99526622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99529037-99529620 Neighboring gene Sharpr-MPRA regulatory region 6151 Neighboring gene MPRA-validated peak3796 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:99656987-99658186 Neighboring gene NANOG hESC enhancer GRCh37_chr2:99698262-99699020 Neighboring gene SMC3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99758101-99758907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99771037-99771658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16277 Neighboring gene chromosome 2 open reading frame 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16280 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99797856-99798028 Neighboring gene lipoyltransferase 1 Neighboring gene microtubule interacting and trafficking domain containing 1 Neighboring gene mitochondrial ribosomal protein L30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Spermatogenic failure 26
MedGen: C4693773 OMIM: 617961 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
testis-specific gene 10 protein
Names
cancer/testis antigen 79
testis development protein NYD-SP7
testis-specific 10 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349012.1NP_001335941.1  testis-specific gene 10 protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC019097, AC092587, AC110083
    Consensus CDS
    CCDS2037.1
    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Related
    ENSP00000377122.3, ENST00000393482.7
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  2. NM_001349013.2NP_001335942.1  testis-specific gene 10 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks three alternate in-frame exons in the 5' coding region compared to variant 1. Both variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AC019097, AC092587, AC110083
    UniProtKB/TrEMBL
    B2R8F9
    Conserved Domains (2) summary
    cl25632
    Location:90280
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    cl25732
    Location:214490
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001349014.1NP_001335943.1  testis-specific gene 10 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks three alternate in-frame exons in the 5' coding region compared to variant 1. Both variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AC019097, AC092587
    UniProtKB/TrEMBL
    B2R8F9
    Conserved Domains (2) summary
    cl25632
    Location:90280
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    cl25732
    Location:214490
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_025244.4NP_079520.1  testis-specific gene 10 protein isoform 1

    See identical proteins and their annotated locations for NP_079520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC019097, AC092587, AF254756, BX647157, DB085678, DC396566
    Consensus CDS
    CCDS2037.1
    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Related
    ENSP00000377123.3, ENST00000393483.8
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  5. NM_182911.4NP_878915.2  testis-specific gene 10 protein isoform 1

    See identical proteins and their annotated locations for NP_878915.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC019097, AC092587, AF254756, BC028366, BI562202
    Consensus CDS
    CCDS2037.1
    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Related
    ENSP00000347161.4, ENST00000355053.8
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)

RNA

  1. NR_146001.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate first exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC019097, AC092587, AC110083
  2. NR_146053.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC092587, BE044403, BX490754
    Related
    ENST00000465216.1
  3. NR_146054.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC092587, BE044403
  4. NR_146055.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC092587, BE044403
    Related
    ENST00000489348.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    98997261..99154966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445934.1XP_047301890.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  2. XM_047445931.1XP_047301887.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  3. XM_047445932.1XP_047301888.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  4. XM_017005041.3XP_016860530.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  5. XM_047445929.1XP_047301885.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  6. XM_047445930.1XP_047301886.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  7. XM_047445928.1XP_047301884.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  8. XM_047445933.1XP_047301889.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  9. XM_005264023.2XP_005264080.1  testis-specific gene 10 protein isoform X6

    See identical proteins and their annotated locations for XP_005264080.1

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Related
    ENSP00000386508.2, ENST00000409564.6
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  10. XM_017005035.2XP_016860524.1  testis-specific gene 10 protein isoform X2

    UniProtKB/TrEMBL
    A0A669KBL0
  11. XM_011511935.4XP_011510237.1  testis-specific gene 10 protein isoform X4

    UniProtKB/TrEMBL
    B2R8F9
    Conserved Domains (3) summary
    COG1196
    Location:268632
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4372
    Location:540743
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    TIGR02168
    Location:70399
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  12. XM_011511934.1XP_011510236.1  testis-specific gene 10 protein isoform X1

    UniProtKB/TrEMBL
    A0A669KBL0
    Related
    ENSP00000501312.1, ENST00000674128.1
    Conserved Domains (1) summary
    pfam05377
    Location:5096
    FlaC_arch; Flagella accessory protein C (FlaC)
  13. XM_017005044.2XP_016860533.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  14. XM_024453158.2XP_024308926.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Related
    ENSP00000386956.1, ENST00000410001.5
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  15. XM_006712781.3XP_006712844.1  testis-specific gene 10 protein isoform X6

    See identical proteins and their annotated locations for XP_006712844.1

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  16. XM_017005046.2XP_016860535.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
    Conserved Domains (2) summary
    cl25732
    Location:140504
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:412615
    DUF3084; Protein of unknown function (DUF3084)
  17. XM_017005037.1XP_016860526.1  testis-specific gene 10 protein isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    99455791..99613837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344073.1XP_054200048.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  2. XM_054344063.1XP_054200038.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  3. XM_054344064.1XP_054200039.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  4. XM_054344068.1XP_054200043.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  5. XM_054344061.1XP_054200036.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  6. XM_054344062.1XP_054200037.1  testis-specific gene 10 protein isoform X3

    UniProtKB/TrEMBL
    A0A669KBL0
  7. XM_054344069.1XP_054200044.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  8. XM_054344067.1XP_054200042.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  9. XM_054344065.1XP_054200040.1  testis-specific gene 10 protein isoform X4

    UniProtKB/TrEMBL
    B2R8F9
  10. XM_054344059.1XP_054200034.1  testis-specific gene 10 protein isoform X1

    UniProtKB/TrEMBL
    A0A669KBL0
  11. XM_054344060.1XP_054200035.1  testis-specific gene 10 protein isoform X2

    UniProtKB/TrEMBL
    A0A669KBL0
  12. XM_054344070.1XP_054200045.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  13. XM_054344071.1XP_054200046.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  14. XM_054344072.1XP_054200047.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  15. XM_054344074.1XP_054200049.1  testis-specific gene 10 protein isoform X6

    UniProtKB/Swiss-Prot
    B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
    UniProtKB/TrEMBL
    A0A218MIY9, B2R8F9
  16. XM_054344066.1XP_054200041.1  testis-specific gene 10 protein isoform X5