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Lzts1 leucine zipper, putative tumor suppressor 1 [ Mus musculus (house mouse) ]

Gene ID: 211134, updated on 8-Feb-2024

Summary

Official Symbol
Lzts1provided by MGI
Official Full Name
leucine zipper, putative tumor suppressor 1provided by MGI
Primary source
MGI:MGI:2684762
See related
Ensembl:ENSMUSG00000036306 AllianceGenome:MGI:2684762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F37; FEZ1; PSD-Zip70
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in negative regulation of macroautophagy; regulation of dendrite morphogenesis; and regulation of synaptic plasticity. Predicted to be located in several cellular components, including apical plasma membrane; dendritic shaft; and postsynaptic density. Predicted to be active in dendritic spine. Is expressed in several structures, including brain and metanephros. Human ortholog(s) of this gene implicated in esophageal cancer and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 14.3), cortex adult (RPKM 13.3) and 14 other tissues See more
Orthologs
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Genomic context

See Lzts1 in Genome Data Viewer
Location:
8 B3.3; 8 33.88 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (69585311..69636901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69132659..69184249, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33103 Neighboring gene predicted gene, 33052 Neighboring gene STARR-seq mESC enhancer starr_21713 Neighboring gene STARR-seq mESC enhancer starr_21714 Neighboring gene solute carrier family 18 (vesicular monoamine), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E8237 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit B2 Neighboring gene STARR-positive B cell enhancer ABC_E8238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71645510-71645697 Neighboring gene predicted gene, 39187 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71700363-71700564 Neighboring gene STARR-positive B cell enhancer ABC_E6640 Neighboring gene STARR-positive B cell enhancer ABC_E3775 Neighboring gene STARR-seq mESC enhancer starr_21725 Neighboring gene predicted gene, 39188 Neighboring gene zinc finger protein 930 Neighboring gene predicted gene, 33178

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine zipper putative tumor suppressor 1
Names
F37 esophageal cancer-related leucine zipper motif 1
F37/Esophageal cancer-related gene-coding leucine-zipper motif
leucine-zipper protein FEZ1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370971.1NP_001357900.1  leucine zipper putative tumor suppressor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC114995
    Consensus CDS
    CCDS22345.1
    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Related
    ENSMUSP00000139117.2, ENSMUST00000185176.8
    Conserved Domains (2) summary
    COG1196
    Location:210480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378567
    Fez1
  2. NM_199364.3NP_955396.2  leucine zipper putative tumor suppressor 1

    See identical proteins and their annotated locations for NP_955396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC114995
    Consensus CDS
    CCDS22345.1
    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Conserved Domains (2) summary
    COG1196
    Location:210480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378567
    Fez1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    69585311..69636901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509608.5XP_006509671.1  leucine zipper putative tumor suppressor 1 isoform X1

    See identical proteins and their annotated locations for XP_006509671.1

    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Conserved Domains (2) summary
    COG1196
    Location:210480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378567
    Fez1
  2. XM_030243384.2XP_030099244.1  leucine zipper putative tumor suppressor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Conserved Domains (2) summary
    COG1196
    Location:210480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378567
    Fez1
  3. XM_030243385.2XP_030099245.1  leucine zipper putative tumor suppressor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RTI1, P60853
    UniProtKB/TrEMBL
    A0PJT4
    Conserved Domains (2) summary
    COG1196
    Location:210480
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:378567
    Fez1