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LZTS1 leucine zipper tumor suppressor 1 [ Homo sapiens (human) ]

Gene ID: 11178, updated on 25-Nov-2021

Summary

Official Symbol
LZTS1provided by HGNC
Official Full Name
leucine zipper tumor suppressor 1provided by HGNC
Primary source
HGNC:HGNC:13861
See related
Ensembl:ENSG00000061337 MIM:606551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F37; FEZ1
Summary
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
Expression
Broad expression in testis (RPKM 4.1), brain (RPKM 3.1) and 19 other tissues See more
Orthologs
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Genomic context

See LZTS1 in Genome Data Viewer
Location:
8p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (20246165..20303963, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (20103676..20161474, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit B2 Neighboring gene RNA, U6 small nuclear 892, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10012 Neighboring gene LZTS1 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 257 Neighboring gene uncharacterized LOC105379314 Neighboring gene uncharacterized LOC107986881

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
GeneReviews: Not available
Genome-wide association scan of dental caries in the permanent dentition.
GeneReviews: Not available
Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
GeneReviews: Not available
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available
Malignant tumor of esophagus
MedGen: C0546837 OMIM: 133239 GeneReviews: Not available
Compare labs
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine zipper putative tumor suppressor 1
Names
F37/Esophageal cancer-related gene-coding leucine-zipper motif
leucine zipper, putative tumor suppressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015834.3 RefSeqGene

    Range
    5019..62817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001362884.2NP_001349813.1  leucine zipper putative tumor suppressor 1

    Status: REVIEWED

    Source sequence(s)
    AC025853, AF123659, BX344344, HY107963
    Consensus CDS
    CCDS6015.1
    Conserved Domains (2) summary
    pfam06818
    Location:380564
    Fez1; Fez1
    cl25732
    Location:235513
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_021020.5NP_066300.1  leucine zipper putative tumor suppressor 1

    See identical proteins and their annotated locations for NP_066300.1

    Status: REVIEWED

    Source sequence(s)
    AC025853, AF123659, BX344344, HY107963
    Consensus CDS
    CCDS6015.1
    UniProtKB/Swiss-Prot
    Q9Y250
    Related
    ENSP00000370981.1, ENST00000381569.5
    Conserved Domains (2) summary
    pfam06818
    Location:380564
    Fez1; Fez1
    cl25732
    Location:235513
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    20246165..20303963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544385.2XP_011542687.1  leucine zipper putative tumor suppressor 1 isoform X1

    See identical proteins and their annotated locations for XP_011542687.1

    UniProtKB/Swiss-Prot
    Q9Y250
    Related
    ENSP00000265801.6, ENST00000265801.6
    Conserved Domains (2) summary
    pfam06818
    Location:380564
    Fez1; Fez1
    cl25732
    Location:235513
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_011544386.2XP_011542688.1  leucine zipper putative tumor suppressor 1 isoform X1

    See identical proteins and their annotated locations for XP_011542688.1

    UniProtKB/Swiss-Prot
    Q9Y250
    Conserved Domains (2) summary
    pfam06818
    Location:380564
    Fez1; Fez1
    cl25732
    Location:235513
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_011544384.2XP_011542686.1  leucine zipper putative tumor suppressor 1 isoform X1

    See identical proteins and their annotated locations for XP_011542686.1

    UniProtKB/Swiss-Prot
    Q9Y250
    Conserved Domains (2) summary
    pfam06818
    Location:380564
    Fez1; Fez1
    cl25732
    Location:235513
    SMC_N; RecF/RecN/SMC N terminal domain
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