Metrnl meteorin, glial cell differentiation regulator-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Metrnlprovided by MGI
Official Full Name: meteorin, glial cell differentiation regulator-likeprovided by MGI
Primary source: MGI:MGI:2384806
See related: Ensembl:ENSMUSG00000039208 AllianceGenome:MGI:2384806
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9430048M07Rik
Summary: Enables hormone activity. Involved in several processes, including brown fat cell differentiation; positive regulation of brown fat cell differentiation; and response to muscle activity. Located in extracellular space. Is expressed in central nervous system; sensory organ; skeleton; and vibrissa. Orthologous to human METRNL (meteorin like, glial cell differentiation regulator). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Broad expression in ovary adult (RPKM 47.4), duodenum adult (RPKM 44.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 86.89 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (121593253..121608215)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (121702427..121717389)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Metrnl improves diabetic kidney disease by inhibiting the TGF-beta1/Smads signaling pathway: A potential therapeutic target.
Title: Upregulation of Metrnl improves diabetic kidney disease by inhibiting the TGF-β1/Smads signaling pathway: A potential therapeutic target.
Metrnl inhibits choroidal neovascularization by attenuating the choroidal inflammation via inactivating the UCHL-1/NF-kappaB signaling pathway.
Title: Metrnl inhibits choroidal neovascularization by attenuating the choroidal inflammation via inactivating the UCHL-1/NF-κB signaling pathway.
Meteorin-like/Meteorin-beta protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway.
Title: Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway.
Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy.
Title: Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy.
Protective role of the novel cytokine Metrnl/ interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 immune cell balance.
Title: Protective role of the novel cytokine Metrnl/ interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 immune cell balance.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Title: Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice.
Title: Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice.
The role of Meteorin-like in skeletal development and bone fracture healing.
Title: The role of Meteorin-like in skeletal development and bone fracture healing.
Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization.
Title: Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization.
Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
Title: Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in energy homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in energy homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of brown fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cold	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: meteorin-like protein

Names: cometin; subfatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.