Metrnl meteorin, glial cell differentiation regulator-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Metrnlprovided by MGI
Official Full Name: meteorin, glial cell differentiation regulator-likeprovided by MGI
Primary source: MGI:MGI:2384806
See related: Ensembl:ENSMUSG00000039208 AllianceGenome:MGI:2384806
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9430048M07Rik
Summary: Enables hormone activity. Involved in several processes, including brown fat cell differentiation; energy homeostasis; and positive regulation of brown fat cell differentiation. Located in extracellular space. Is expressed in central nervous system; sensory organ; skeleton; and vibrissa. Orthologous to human METRNL (meteorin like, glial cell differentiation regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 47.4), duodenum adult (RPKM 44.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 E2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (121593253..121608215)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (121702427..121717389)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of Meteorin-like in skeletal development and bone fracture healing.
Title: The role of Meteorin-like in skeletal development and bone fracture healing.
Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization.
Title: Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization.
Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
Title: Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like.
Title: Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like.
Meteorin-like/Meteorin-beta protects heart against cardiac dysfunction.
Title: Meteorin-like/Meteorin-β protects heart against cardiac dysfunction.
The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKalpha2.
Title: The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2.
Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells.
Title: Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells.
Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
Title: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
these observations indicate that Metrnl encodes a novel immunoregulatory cytokine associated with inflammatory responses
Title: Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation.
METRNL alleviates inflammation and insulin resistance and induces fatty acid oxidation through AMPK or PPARdelta-dependent signaling in skeletal muscle.
Title: METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

General gene information

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Homology

Homologs of the Metrnl gene: The Metrnl gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 468 organisms have orthologs with human gene Metrnl
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in energy homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in energy homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of brown fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cold	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: meteorin-like protein

Names: cometin; subfatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.