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METRNL meteorin like, glial cell differentiation regulator [ Homo sapiens (human) ]

Gene ID: 284207, updated on 23-Nov-2021

Summary

Official Symbol
METRNLprovided by HGNC
Official Full Name
meteorin like, glial cell differentiation regulatorprovided by HGNC
Primary source
HGNC:HGNC:27584
See related
Ensembl:ENSG00000176845 MIM:616241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in colon (RPKM 12.0), kidney (RPKM 11.4) and 25 other tissues See more
Orthologs
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Genomic context

See METRNL in Genome Data Viewer
Location:
17q25.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (83079609..83095122)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (81037485..81052867)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tubulin folding cofactor D Neighboring gene TBCD intron CAGE-defined B cell enhancer Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 Neighboring gene Sharpr-MPRA regulatory region 7018 Neighboring gene uncharacterized LOC107987251 Neighboring gene CAGE-defined high expression enhancer downstream of METRNL Neighboring gene uncharacterized LOC101930496

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99788

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in energy homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of brown fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to cold ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to muscle activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
meteorin-like protein
Names
cometin
meteorin, glial cell differentiation regulator-like
subfatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004431.3NP_001004431.1  meteorin-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004431.1

    Status: VALIDATED

    Source sequence(s)
    AC130371, BC082252, CF264755, DR760693
    Consensus CDS
    CCDS32779.1
    UniProtKB/Swiss-Prot
    Q641Q3
    Related
    ENSP00000315731.6, ENST00000320095.12
  2. NM_001363853.2NP_001350782.1  meteorin-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130371
    Consensus CDS
    CCDS86656.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    83079609..83095122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024523.1XP_016880012.1  meteorin-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q641Q3
    Related
    ENSP00000460798.1, ENST00000571814.1

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187612.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    8456..24216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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