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Syt3 synaptotagmin III [ Mus musculus (house mouse) ]

Gene ID: 20981, updated on 9-Sep-2018

Summary

Official Symbol
Syt3provided by MGI
Official Full Name
synaptotagmin IIIprovided by MGI
Primary source
MGI:MGI:99665
See related
Ensembl:ENSMUSG00000030731 Vega:OTTMUSG00000031834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sytIII; AI385753
Expression
Biased expression in cerebellum adult (RPKM 17.0), cortex adult (RPKM 9.0) and 14 other tissues See more
Orthologs

Genomic context

See Syt3 in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44384099..44400030)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51639496..51655400)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene predicted gene, 39001 Neighboring gene predicted gene, 39002 Neighboring gene leucine rich repeat containing 4B Neighboring gene predicted gene, 39003

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
calcium ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114116.1NP_001107588.1  synaptotagmin-3

    See identical proteins and their annotated locations for NP_001107588.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC152939, AU080420, BC051969
    Consensus CDS
    CCDS21205.1
    UniProtKB/Swiss-Prot
    O35681
    UniProtKB/TrEMBL
    G3X9Y1
    Related
    ENSMUSP00000114070.1, OTTMUSP00000042038, ENSMUST00000118962.7, OTTMUST00000078933
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  2. NM_016663.3NP_057872.3  synaptotagmin-3

    See identical proteins and their annotated locations for NP_057872.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC152939, AU080420, BC051969, BY293405
    Consensus CDS
    CCDS21205.1
    UniProtKB/Swiss-Prot
    O35681
    UniProtKB/TrEMBL
    G3X9Y1
    Related
    ENSMUSP00000112432.1, OTTMUSP00000042037, ENSMUST00000118831.7, OTTMUST00000078932
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    44384099..44400030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322088.1XP_017177577.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  2. XM_017322089.1XP_017177578.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  3. XM_006540755.2XP_006540818.1  synaptotagmin-3 isoform X1

    See identical proteins and their annotated locations for XP_006540818.1

    UniProtKB/TrEMBL
    G3X9Y1
    Related
    ENSMUSP00000112968.1, OTTMUSP00000042039, ENSMUST00000120262.1, OTTMUST00000078934
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  4. XM_017322087.1XP_017177576.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
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