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Syt3 synaptotagmin III [ Mus musculus (house mouse) ]

Gene ID: 20981, updated on 4-Mar-2023

Summary

Official Symbol
Syt3provided by MGI
Official Full Name
synaptotagmin IIIprovided by MGI
Primary source
MGI:MGI:99665
See related
Ensembl:ENSMUSG00000030731 AllianceGenome:MGI:99665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sytIII
Summary
Enables calcium-dependent phospholipid binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of dendrite extension; regulation of dopamine secretion; and regulation of vesicle-mediated transport. Predicted to act upstream of or within cell differentiation and exocytosis. Predicted to be located in endosome. Predicted to be active in exocytic vesicle and plasma membrane. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human SYT3 (synaptotagmin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 17.0), cortex adult (RPKM 9.0) and 14 other tissues See more
Orthologs
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Genomic context

See Syt3 in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44032197..44049454)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44382773..44400030)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene predicted gene, 39001 Neighboring gene predicted gene, 39002 Neighboring gene leucine rich repeat containing 4B Neighboring gene predicted gene, 39003

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114116.2NP_001107588.1  synaptotagmin-3

    See identical proteins and their annotated locations for NP_001107588.1

    Status: VALIDATED

    Source sequence(s)
    AC152939
    Consensus CDS
    CCDS21205.1
    UniProtKB/Swiss-Prot
    O35681
    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Related
    ENSMUSP00000114070.2, ENSMUST00000118962.8
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  2. NM_001417323.1NP_001404252.1  synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    AC152939
  3. NM_001417324.1NP_001404253.1  synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    AC152939
  4. NM_001417325.1NP_001404254.1  synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    AC152939
  5. NM_001417326.1NP_001404255.1  synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    AC152939
  6. NM_016663.4NP_057872.3  synaptotagmin-3

    See identical proteins and their annotated locations for NP_057872.3

    Status: VALIDATED

    Source sequence(s)
    AC152939
    Consensus CDS
    CCDS21205.1
    UniProtKB/Swiss-Prot
    O35681
    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Related
    ENSMUSP00000112432.2, ENSMUST00000118831.8
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44032197..44049454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242318.1XP_030098178.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  2. XM_036152863.1XP_036008756.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  3. XM_017322088.1XP_017177577.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  4. XM_017322089.1XP_017177578.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  5. XM_030242319.1XP_030098179.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  6. XM_006540755.2XP_006540818.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Related
    ENSMUSP00000112968.2, ENSMUST00000120262.2
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  7. XM_036152864.1XP_036008757.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  8. XM_017322087.2XP_017177576.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  9. XM_030242317.2XP_030098177.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GWM2, G3X9Y1
    Conserved Domains (2) summary
    cd08385
    Location:297421
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:430564
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10