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Supt5 suppressor of Ty 5, DSIF elongation factor subunit [ Mus musculus (house mouse) ]

Gene ID: 20924, updated on 30-Apr-2024

Summary

Official Symbol
Supt5provided by MGI
Official Full Name
suppressor of Ty 5, DSIF elongation factor subunitprovided by MGI
Primary source
MGI:MGI:1202400
See related
Ensembl:ENSMUSG00000003435 AllianceGenome:MGI:1202400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spt5; Supt5h
Summary
Enables chromatin binding activity. Predicted to be involved in positive regulation of macroautophagy; regulation of RNA metabolic process; and transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleoplasm. Predicted to be part of DSIF complex. Is expressed in several structures, including genitourinary system; limb mesenchyme; and nervous system. Orthologous to human SUPT5H (SPT5 homolog, DSIF elongation factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 68.8), adrenal adult (RPKM 67.5) and 28 other tissues See more
Orthologs
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Genomic context

See Supt5 in Genome Data Viewer
Location:
7 A3; 7 16.68 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28014316..28038341, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28314891..28338804, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene delta like canonical Notch ligand 3 Neighboring gene STARR-positive B cell enhancer ABC_E6527 Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene predicted gene, 51445 Neighboring gene STARR-seq mESC enhancer starr_18409 Neighboring gene STARR-positive B cell enhancer ABC_E3708 Neighboring gene snoRNA AF357399 Neighboring gene ribosomal protein S16 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2 Neighboring gene STARR-positive B cell enhancer ABC_E445 Neighboring gene nuclear encoded tRNA isoleucine 16 (anticodon TAT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DSIF complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of DSIF complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription elongation factor SPT5
Names
DRB sensitivity-inducing factor large subunit
DSIF large subunit
suppressor of Ty 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417308.1NP_001404237.1  transcription elongation factor SPT5 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC148986
  2. NM_001417309.1NP_001404238.1  transcription elongation factor SPT5 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC148986
    Related
    ENSMUST00000207879.2
  3. NM_001417310.1NP_001404239.1  transcription elongation factor SPT5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC148986
  4. NM_013676.2NP_038704.1  transcription elongation factor SPT5 isoform a

    See identical proteins and their annotated locations for NP_038704.1

    Status: VALIDATED

    Source sequence(s)
    AC148986
    Consensus CDS
    CCDS39857.1
    UniProtKB/Swiss-Prot
    O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4
    Related
    ENSMUSP00000003527.9, ENSMUST00000003527.10
    Conserved Domains (12) summary
    PRK08559
    Location:173314
    nusG; transcription antitermination protein NusG; Validated
    cd09888
    Location:176263
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    COG5164
    Location:332959
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:274311
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06082
    Location:418468
    KOW_Spt5_2; KOW domain of Spt5, repeat 2
    cd06083
    Location:469519
    KOW_Spt5_3; KOW domain of Spt5, repeat 3
    cd06084
    Location:595637
    KOW_Spt5_4; KOW domain of Spt5, repeat 4
    cd06085
    Location:696745
    KOW_Spt5_5; KOW domain of Spt5, repeat 5
    cd06086
    Location:10221079
    KOW_Spt5_6; KOW domain of Spt5, repeat 6
    pfam04731
    Location:841970
    Caudal_act; Caudal like protein activation region
    pfam11942
    Location:91169
    Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
    pfam12815
    Location:760816
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28014316..28038341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539703.3XP_006539766.1  transcription elongation factor SPT5 isoform X2

    Conserved Domains (5) summary
    cd09888
    Location:176263
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    COG5164
    Location:332906
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:274311
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06086
    Location:9691026
    KOW_Spt5_6; KOW domain of Spt5, repeat 6
    pfam11942
    Location:73169
    Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
  2. XM_036152859.1XP_036008752.1  transcription elongation factor SPT5 isoform X3

    Conserved Domains (4) summary
    cd09888
    Location:37124
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    COG5164
    Location:193820
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:135172
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06086
    Location:883940
    KOW_Spt5_6; KOW domain of Spt5, repeat 6