U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eif1 eukaryotic translation initiation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 20918, updated on 26-Sep-2022

Summary

Official Symbol
Eif1provided by MGI
Official Full Name
eukaryotic translation initiation factor 1provided by MGI
Primary source
MGI:MGI:105125
See related
Ensembl:ENSMUSG00000035530 AllianceGenome:MGI:105125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sui1-rs1
Summary
Predicted to enable ribosomal small subunit binding activity and translation initiation factor activity. Acts upstream of or within dosage compensation by inactivation of X chromosome. Predicted to be located in cytoplasm and nucleus. Predicted to be part of eukaryotic 43S preinitiation complex. Is expressed in germ cell of testis and testis. Orthologous to human EIF1 (eukaryotic translation initiation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 117.5), liver E14 (RPKM 95.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Eif1 in Genome Data Viewer
Location:
11; 11 D
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100210775..100212925)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100319949..100322099)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 42 Neighboring gene predicted gene 14206 Neighboring gene gastrin Neighboring gene huntingtin-associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6503, MGC101938

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within dosage compensation by inactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic 43S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 1
Names
protein translation factor SUI1 homolog
suppressor of initiator codon mutations, related sequence 1
suppressor of initiator codon mutations-Yeast homolog related sequence 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011508.2NP_035638.1  eukaryotic translation initiation factor 1

    See identical proteins and their annotated locations for NP_035638.1

    Status: VALIDATED

    Source sequence(s)
    AK151070, AL590968, CD773876
    Consensus CDS
    CCDS25417.1
    UniProtKB/Swiss-Prot
    P48024, Q9WUD5
    UniProtKB/TrEMBL
    A0A8C6G610, Q4V9T8
    Related
    ENSMUSP00000041538.8, ENSMUST00000049385.14
    Conserved Domains (1) summary
    cl00229
    Location:3113
    eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100210775..100212925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)