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EIF1 eukaryotic translation initiation factor 1 [ Homo sapiens (human) ]

Gene ID: 10209, updated on 4-Dec-2022

Summary

Official Symbol
EIF1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 1provided by HGNC
Primary source
HGNC:HGNC:3249
See related
Ensembl:ENSG00000173812 MIM:619901; AllianceGenome:HGNC:3249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A121; ISO1; SUI1; EIF-1; EIF1A
Summary
Enables RNA binding activity. Involved in regulation of translational initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 681.9), fat (RPKM 274.0) and 25 other tissues See more
Orthologs
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Genomic context

See EIF1 in Genome Data Viewer
Location:
17q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41688885..41692668)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42545340..42549123)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39845137..39848920)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 42, pseudogene Neighboring gene uncharacterized LOC124904004 Neighboring gene RNA, 5S ribosomal pseudogene 442 Neighboring gene gastrin Neighboring gene huntingtin associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic 43S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 1
Names
protein translation factor SUI1 homolog
sui1iso1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005801.4NP_005792.1  eukaryotic translation initiation factor 1

    See identical proteins and their annotated locations for NP_005792.1

    Status: VALIDATED

    Source sequence(s)
    AA159721, AC130686, BC005118, BU165055
    Consensus CDS
    CCDS11403.1
    UniProtKB/Swiss-Prot
    P41567, Q9UNQ9
    UniProtKB/TrEMBL
    Q6IAV3
    Related
    ENSP00000419449.1, ENST00000469257.2
    Conserved Domains (1) summary
    cl00229
    Location:3113
    eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    41688885..41692668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    42545340..42549123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)