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Eif4g1 eukaryotic translation initiation factor 4, gamma 1 [ Mus musculus (house mouse) ]

Gene ID: 208643, updated on 8-Feb-2024

Summary

Official Symbol
Eif4g1provided by MGI
Official Full Name
eukaryotic translation initiation factor 4, gamma 1provided by MGI
Primary source
MGI:MGI:2384784
See related
Ensembl:ENSMUSG00000045983 AllianceGenome:MGI:2384784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
eIF4GI; eIF-4G1; eIF-4G 1; E030015G23Rik; eIF-4-gamma 1
Summary
This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 72.7), limb E14.5 (RPKM 65.1) and 28 other tissues See more
Orthologs
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Genomic context

See Eif4g1 in Genome Data Viewer
Location:
16 A3; 16 12.49 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20491457..20511633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20672720..20692883)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene STARR-seq mESC enhancer starr_40329 Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene STARR-positive B cell enhancer ABC_E1489 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC37551, MGC90776

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic initiation factor 4E binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation factor activity, RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in macromolecule biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA cap binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell periphery ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in translation ISO
Inferred from Sequence Orthology
more info
 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 4F complex ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4 gamma 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304432.2NP_001291361.1  eukaryotic translation initiation factor 4 gamma 1 isoform c

    See identical proteins and their annotated locations for NP_001291361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC087898
    Consensus CDS
    CCDS84213.1
    UniProtKB/TrEMBL
    A0A0J9YUS5
    Related
    ENSMUSP00000111123.2, ENSMUST00000115463.8
    Conserved Domains (3) summary
    cd11559
    Location:14271556
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12281340
    MA3; MA3 domain
    pfam02854
    Location:758986
    MIF4G; MIF4G domain
  2. NM_001403460.1NP_001390389.1  eukaryotic translation initiation factor 4 gamma 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5, E9PVC5
    Related
    ENSMUSP00000111121.2, ENSMUST00000115461.8
  3. NM_001403461.1NP_001390390.1  eukaryotic translation initiation factor 4 gamma 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5, E9PVC5
  4. NM_001403462.1NP_001390391.1  eukaryotic translation initiation factor 4 gamma 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5, E9Q9E1
    Related
    ENSMUSP00000073506.6, ENSMUST00000073840.12
  5. NM_001403463.1NP_001390392.1  eukaryotic translation initiation factor 4 gamma 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5
  6. NM_001403464.1NP_001390393.1  eukaryotic translation initiation factor 4 gamma 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5
  7. NM_001403465.1NP_001390394.1  eukaryotic translation initiation factor 4 gamma 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5
  8. NM_001403466.1NP_001390395.1  eukaryotic translation initiation factor 4 gamma 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5, E9PVC6
  9. NM_001403467.1NP_001390396.1  eukaryotic translation initiation factor 4 gamma 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5
  10. NM_001403468.1NP_001390397.1  eukaryotic translation initiation factor 4 gamma 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    A0A0J9YUS5
    Related
    ENSMUST00000132320.8
  11. NM_145941.4NP_666053.2  eukaryotic translation initiation factor 4 gamma 1 isoform a

    See identical proteins and their annotated locations for NP_666053.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC087898
    Consensus CDS
    CCDS28055.1
    UniProtKB/Swiss-Prot
    Q6NZJ6, Q6NZN8, Q8BW99
    UniProtKB/TrEMBL
    A0A0J9YUS5
    Related
    ENSMUSP00000047678.8, ENSMUST00000044783.14
    Conserved Domains (5) summary
    cd11559
    Location:14411570
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:4463
    PHA03247; large tegument protein UL36; Provisional
    TIGR00600
    Location:373612
    rad2; DNA excision repair protein (rad2)
    pfam02847
    Location:12421354
    MA3; MA3 domain
    pfam02854
    Location:765993
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20491457..20511633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521935.2XP_006521998.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

    See identical proteins and their annotated locations for XP_006521998.1

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (5) summary
    cd11559
    Location:14421571
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:4463
    PHA03247; large tegument protein UL36; Provisional
    TIGR00600
    Location:373612
    rad2; DNA excision repair protein (rad2)
    pfam02847
    Location:12431355
    MA3; MA3 domain
    pfam02854
    Location:766994
    MIF4G; MIF4G domain
  2. XM_006521937.2XP_006522000.1  eukaryotic translation initiation factor 4 gamma 1 isoform X2

    See identical proteins and their annotated locations for XP_006522000.1

    UniProtKB/Swiss-Prot
    Q6NZJ6, Q6NZN8, Q8BW99
    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (5) summary
    cd11559
    Location:14411570
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:4463
    PHA03247; large tegument protein UL36; Provisional
    TIGR00600
    Location:373612
    rad2; DNA excision repair protein (rad2)
    pfam02847
    Location:12421354
    MA3; MA3 domain
    pfam02854
    Location:765993
    MIF4G; MIF4G domain
  3. XM_011245861.2XP_011244163.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (4) summary
    cd11559
    Location:14321561
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:7560
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:12331345
    MA3; MA3 domain
    pfam02854
    Location:756984
    MIF4G; MIF4G domain
  4. XM_030249023.2XP_030104883.1  eukaryotic translation initiation factor 4 gamma 1 isoform X6

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (4) summary
    cd11559
    Location:14311560
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:7560
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:12321344
    MA3; MA3 domain
    pfam02854
    Location:755983
    MIF4G; MIF4G domain
  5. XM_006521940.5XP_006522003.1  eukaryotic translation initiation factor 4 gamma 1 isoform X4

    UniProtKB/TrEMBL
    A0A0J9YUS5, E9Q9E1
    Conserved Domains (5) summary
    cd11559
    Location:14341563
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:4456
    PHA03247; large tegument protein UL36; Provisional
    TIGR00600
    Location:366605
    rad2; DNA excision repair protein (rad2)
    pfam02847
    Location:12351347
    MA3; MA3 domain
    pfam02854
    Location:758986
    MIF4G; MIF4G domain
  6. XM_006521944.4XP_006522007.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (5) summary
    cd11559
    Location:13951524
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:2523
    PHA03247; large tegument protein UL36; Provisional
    pfam05109
    Location:156415
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02847
    Location:11961308
    MA3; MA3 domain
    pfam02854
    Location:719947
    MIF4G; MIF4G domain
  7. XM_006521943.2XP_006522006.1  eukaryotic translation initiation factor 4 gamma 1 isoform X9

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (4) summary
    cd11559
    Location:14021531
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:20530
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:12031315
    MA3; MA3 domain
    pfam02854
    Location:726954
    MIF4G; MIF4G domain
  8. XM_036159852.1XP_036015745.1  eukaryotic translation initiation factor 4 gamma 1 isoform X11

    UniProtKB/TrEMBL
    A0A0J9YUS5, E9PVC6
    Related
    ENSMUSP00000111117.2, ENSMUST00000115457.8
    Conserved Domains (5) summary
    cd11559
    Location:13941523
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:2523
    PHA03247; large tegument protein UL36; Provisional
    pfam05109
    Location:156415
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02847
    Location:11951307
    MA3; MA3 domain
    pfam02854
    Location:718946
    MIF4G; MIF4G domain
  9. XM_036159855.1XP_036015748.1  eukaryotic translation initiation factor 4 gamma 1 isoform X14

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (5) summary
    cd11559
    Location:13841513
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    TIGR00600
    Location:316555
    rad2; DNA excision repair protein (rad2)
    pfam05109
    Location:146405
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02847
    Location:11851297
    MA3; MA3 domain
    pfam02854
    Location:708936
    MIF4G; MIF4G domain
  10. XM_006521936.3XP_006521999.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

    See identical proteins and their annotated locations for XP_006521999.1

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (5) summary
    cd11559
    Location:14421571
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:4463
    PHA03247; large tegument protein UL36; Provisional
    TIGR00600
    Location:373612
    rad2; DNA excision repair protein (rad2)
    pfam02847
    Location:12431355
    MA3; MA3 domain
    pfam02854
    Location:766994
    MIF4G; MIF4G domain
  11. XM_030249025.2XP_030104885.1  eukaryotic translation initiation factor 4 gamma 1 isoform X9

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (4) summary
    cd11559
    Location:14021531
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:20530
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:12031315
    MA3; MA3 domain
    pfam02854
    Location:726954
    MIF4G; MIF4G domain
  12. XM_006521945.2XP_006522008.1  eukaryotic translation initiation factor 4 gamma 1 isoform X12

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (4) summary
    cd11559
    Location:13921521
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:73520
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:11931305
    MA3; MA3 domain
    pfam02854
    Location:716944
    MIF4G; MIF4G domain
  13. XM_030249026.2XP_030104886.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (5) summary
    cd11559
    Location:13951524
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:2523
    PHA03247; large tegument protein UL36; Provisional
    pfam05109
    Location:156415
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02847
    Location:11961308
    MA3; MA3 domain
    pfam02854
    Location:719947
    MIF4G; MIF4G domain
  14. XM_036159856.1XP_036015749.1  eukaryotic translation initiation factor 4 gamma 1 isoform X16

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Related
    ENSMUSP00000144320.2, ENSMUST00000143939.8
    Conserved Domains (4) summary
    cd11559
    Location:13471476
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:19476
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:11481260
    MA3; MA3 domain
    pfam02854
    Location:671899
    MIF4G; MIF4G domain
  15. XM_030249027.2XP_030104887.1  eukaryotic translation initiation factor 4 gamma 1 isoform X17

    UniProtKB/TrEMBL
    A0A0J9YUS5
    Conserved Domains (4) summary
    cd11559
    Location:13381467
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:19466
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:11391251
    MA3; MA3 domain
    pfam02854
    Location:662890
    MIF4G; MIF4G domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005331.1: Suppressed sequence

    Description
    NM_001005331.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.