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EIF4G1 eukaryotic translation initiation factor 4 gamma 1 [ Homo sapiens (human) ]

Gene ID: 1981, updated on 6-Oct-2024

Summary

Official Symbol
EIF4G1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4 gamma 1provided by HGNC
Primary source
HGNC:HGNC:3296
See related
Ensembl:ENSG00000114867 MIM:600495; AllianceGenome:HGNC:3296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1
Summary
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues See more
Orthologs
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Genomic context

See EIF4G1 in Genome Data Viewer
Location:
3q27.1
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (184314606..184335358)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (187123882..187144618)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (184032394..184053146)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene EEF1AKMT4-ECE2 readthrough Neighboring gene endothelin converting enzyme 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14959 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:184031817-184032317 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:184033042-184033663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184045141-184045641 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20908 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:184053938-184054138 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:184055930-184056541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20909 Neighboring gene family with sequence similarity 131 member A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:184061884-184062636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:184062637-184063388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184063389-184064141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184064142-184064893 Neighboring gene chloride voltage-gated channel 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184077025-184077538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184077539-184078050 Neighboring gene uncharacterized LOC124906311

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Parkinson disease 18, autosomal dominant, susceptibility to
MedGen: C3280271 OMIM: 614251 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of EIF4G1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag The initiation factor eIF4G is required for the synthesis of the Gag polyprotein by a classical cap-dependent mechanism PubMed
Tat tat HIV-1 Tat co-localizes with eIF4G in cytoplasmic stress granules under stress conditions PubMed
retropepsin gag-pol Purified HIV-1 protease cleaves eIF4GI at positions 678, 681, and 1086 leading to inhibition of protein synthesis directed by capped mRNAs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp686A1451

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
involved_in cap-dependent translational initiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to nutrient levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in macromolecule biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in positive regulation of mRNA cap binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to cell periphery IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular response to stress TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of presynapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translation IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translational initiation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4 gamma 1
Names
EIF4-gamma
eIF-4-gamma 1
eucaryotic translation initiation factor 4G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016850.2 RefSeqGene

    Range
    5002..25749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001194946.2NP_001181875.2  eukaryotic translation initiation factor 4 gamma 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS54687.1
    UniProtKB/TrEMBL
    B2RU10
    Related
    ENSP00000371767.3, ENST00000382330.7
    Conserved Domains (4) summary
    cd11559
    Location:14451577
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:21583
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:12491361
    MA3; MA3 domain
    pfam02854
    Location:768993
    MIF4G; MIF4G domain
  2. NM_001194947.2NP_001181876.2  eukaryotic translation initiation factor 4 gamma 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS54687.1
    UniProtKB/TrEMBL
    B2RU10
    Related
    ENSP00000338020.4, ENST00000352767.7
    Conserved Domains (4) summary
    cd11559
    Location:14451577
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:21583
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:12491361
    MA3; MA3 domain
    pfam02854
    Location:768993
    MIF4G; MIF4G domain
  3. NM_001291157.2NP_001278086.2  eukaryotic translation initiation factor 4 gamma 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, includes an additional internal segment in the 5' region, which results in a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus, and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS77866.1
    UniProtKB/TrEMBL
    E7EUU4
    Related
    ENSP00000391935.1, ENST00000414031.5
    Conserved Domains (4) summary
    cd11559
    Location:13981530
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:13536
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:12021314
    MA3; MA3 domain
    pfam02854
    Location:721949
    MIF4G; MIF4G domain
  4. NM_004953.5NP_004944.3  eukaryotic translation initiation factor 4 gamma 1 isoform 4

    See identical proteins and their annotated locations for NP_004944.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC078797, BQ011010
    Consensus CDS
    CCDS46970.2
    UniProtKB/TrEMBL
    E7EX73
    Related
    ENSP00000411826.2, ENST00000434061.6
    Conserved Domains (4) summary
    cd11559
    Location:12431375
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:10471159
    MA3; MA3 domain
    pfam02854
    Location:566791
    MIF4G; MIF4G domain
    pfam08648
    Location:9521053
    DUF1777; Protein of unknown function (DUF1777)
  5. NM_182917.4NP_886553.3  eukaryotic translation initiation factor 4 gamma 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AF002815, AK308319, AY082886, BQ011010, DC347118
    Consensus CDS
    CCDS54688.1
    UniProtKB/TrEMBL
    B2RU10
    Related
    ENSP00000343450.4, ENST00000342981.8
    Conserved Domains (4) summary
    cd11559
    Location:14391571
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12431355
    MA3; MA3 domain
    pfam02854
    Location:762987
    MIF4G; MIF4G domain
    pfam08648
    Location:11481249
    DUF1777; Protein of unknown function (DUF1777)
  6. NM_198241.3NP_937884.2  eukaryotic translation initiation factor 4 gamma 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (5) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS3259.1
    UniProtKB/Swiss-Prot
    D3DNT2, D3DNT4, D3DNT5, E9PFM1, G5E9S1, O43177, O95066, Q04637, Q5HYG0, Q6ZN21, Q8N102
    UniProtKB/TrEMBL
    B2RU10
    Related
    ENSP00000316879.5, ENST00000346169.7
    Conserved Domains (5) summary
    cd11559
    Location:14381570
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:20452
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:405573
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam02847
    Location:12421354
    MA3; MA3 domain
    pfam02854
    Location:761986
    MIF4G; MIF4G domain
  7. NM_198242.3NP_937885.1  eukaryotic translation initiation factor 4 gamma 1 isoform 3

    See identical proteins and their annotated locations for NP_937885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS3261.1
    UniProtKB/TrEMBL
    E7EX73
    Related
    ENSP00000317600.8, ENST00000350481.9
    Conserved Domains (4) summary
    cd11559
    Location:12741406
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:10781190
    MA3; MA3 domain
    pfam02854
    Location:597822
    MIF4G; MIF4G domain
    pfam08648
    Location:9831084
    DUF1777; Protein of unknown function (DUF1777)
  8. NM_198244.3NP_937887.2  eukaryotic translation initiation factor 4 gamma 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS3260.1
    UniProtKB/TrEMBL
    E9PGM1
    Related
    ENSP00000376320.2, ENST00000392537.6
    Conserved Domains (4) summary
    cd11559
    Location:13511483
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:28489
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:11551267
    MA3; MA3 domain
    pfam02854
    Location:674902
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    184314606..184335358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    187123882..187144618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)