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EIF4G1 eukaryotic translation initiation factor 4 gamma 1 [ Homo sapiens (human) ]

Gene ID: 1981, updated on 27-Feb-2020

Summary

Official Symbol
EIF4G1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4 gamma 1provided by HGNC
Primary source
HGNC:HGNC:3296
See related
Ensembl:ENSG00000114867 MIM:600495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1
Summary
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues See more
Orthologs

Genomic context

See EIF4G1 in Genome Data Viewer
Location:
3q27.1
Exon count:
34
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (184314495..184335358)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (184032283..184053146)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene EEF1AKMT4-ECE2 readthrough Neighboring gene endothelin converting enzyme 2 Neighboring gene proteasome 26S subunit, non-ATPase 2 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131 member A Neighboring gene chloride voltage-gated channel 2 Neighboring gene RNA polymerase II subunit H

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Parkinson disease 18
MedGen: C3280271 OMIM: 614251 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of EIF4G1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag The initiation factor eIF4G is required for the synthesis of the Gag polyprotein by a classical cap-dependent mechanism PubMed
Tat tat HIV-1 Tat co-localizes with eIF4G in cytoplasmic stress granules under stress conditions PubMed
retropepsin gag-pol Purified HIV-1 protease cleaves eIF4GI at positions 678, 681, and 1086 leading to inhibition of protein synthesis directed by capped mRNAs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686A1451

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
eukaryotic initiation factor 4E binding IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic initiation factor 4E binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
molecular adaptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation factor activity, RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor activity TAS
Traceable Author Statement
more info
PubMed 
translation initiation factor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
cap-dependent translational initiation TAS
Traceable Author Statement
more info
PubMed 
cellular macromolecule biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to nutrient levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental process TAS
Traceable Author Statement
more info
PubMed 
energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death TAS
Traceable Author Statement
more info
PubMed 
negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of eukaryotic translation initiation factor 4F complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mRNA cap binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to stress TAS
Traceable Author Statement
more info
PubMed 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of polysome binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of presynapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation IPI
Inferred from Physical Interaction
more info
PubMed 
translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
polysome IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4 gamma 1
Names
EIF4-gamma
eIF-4-gamma 1
eucaryotic translation initiation factor 4G

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016850.1 RefSeqGene

    Range
    4928..25791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001194946.2NP_001181875.2  eukaryotic translation initiation factor 4 gamma 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS54687.1
    Related
    ENSP00000371767.3, ENST00000382330.7
  2. NM_001194947.1NP_001181876.1  eukaryotic translation initiation factor 4 gamma 1 isoform 6

    See identical proteins and their annotated locations for NP_001181876.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.
    Source sequence(s)
    BC140896, BQ011010, CR980540
    Consensus CDS
    CCDS54687.1
    UniProtKB/TrEMBL
    B2RU10
    Related
    ENSP00000338020.4, ENST00000352767.7
    Conserved Domains (5) summary
    cd11559
    Location:14451577
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam09606
    Location:24459
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02847
    Location:12491361
    MA3; MA3 domain
    pfam02854
    Location:768993
    MIF4G; MIF4G domain
    pfam08648
    Location:11541255
    DUF1777; Protein of unknown function (DUF1777)
  3. NM_001291157.2NP_001278086.2  eukaryotic translation initiation factor 4 gamma 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, includes an additional internal segment in the 5' region, which results in a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus, and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS77866.1
    Related
    ENSP00000391935.1, ENST00000414031.5
  4. NM_004953.5NP_004944.3  eukaryotic translation initiation factor 4 gamma 1 isoform 4

    See identical proteins and their annotated locations for NP_004944.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC078797, BQ011010
    Consensus CDS
    CCDS46970.2
    UniProtKB/Swiss-Prot
    Q04637
    Related
    ENSP00000411826.2, ENST00000434061.6
    Conserved Domains (4) summary
    cd11559
    Location:12431375
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:10471159
    MA3; MA3 domain
    pfam02854
    Location:566791
    MIF4G; MIF4G domain
    pfam08648
    Location:9521053
    DUF1777; Protein of unknown function (DUF1777)
  5. NM_182917.4NP_886553.3  eukaryotic translation initiation factor 4 gamma 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AF002815, AK308319, AY082886, BQ011010, DC347118
    Consensus CDS
    CCDS54688.1
    UniProtKB/Swiss-Prot
    Q04637
    UniProtKB/TrEMBL
    O95065
    Related
    ENSP00000343450.4, ENST00000342981.8
    Conserved Domains (4) summary
    cd11559
    Location:14391571
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12431355
    MA3; MA3 domain
    pfam02854
    Location:762987
    MIF4G; MIF4G domain
    pfam08648
    Location:11481249
    DUF1777; Protein of unknown function (DUF1777)
  6. NM_198241.3NP_937884.2  eukaryotic translation initiation factor 4 gamma 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (5) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS3259.1
    Related
    ENSP00000316879.4, ENST00000346169.6
  7. NM_198242.3NP_937885.1  eukaryotic translation initiation factor 4 gamma 1 isoform 3

    See identical proteins and their annotated locations for NP_937885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS3261.1
    UniProtKB/Swiss-Prot
    Q04637
    Related
    ENSP00000317600.8, ENST00000350481.9
    Conserved Domains (4) summary
    cd11559
    Location:12741406
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:10781190
    MA3; MA3 domain
    pfam02854
    Location:597822
    MIF4G; MIF4G domain
    pfam08648
    Location:9831084
    DUF1777; Protein of unknown function (DUF1777)
  8. NM_198244.3NP_937887.2  eukaryotic translation initiation factor 4 gamma 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AC078797
    Consensus CDS
    CCDS3260.1
    Related
    ENSP00000376320.2, ENST00000392537.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    184314495..184335358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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