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Kntc1 kinetochore associated 1 [ Mus musculus (house mouse) ]

Gene ID: 208628, updated on 5-Mar-2024

Summary

Official Symbol
Kntc1provided by MGI
Official Full Name
kinetochore associated 1provided by MGI
Primary source
MGI:MGI:2673709
See related
Ensembl:ENSMUSG00000029414 AllianceGenome:MGI:2673709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
jgl; D330012D13
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore involved in kinetochore assembly. Predicted to act upstream of or within cell division. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be part of RZZ complex. Predicted to be active in cytoplasm and kinetochore microtubule. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and spleen. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 6.3) and 14 other tissues See more
Orthologs
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Genomic context

See Kntc1 in Genome Data Viewer
Location:
5 F; 5 63.17 cM
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123887755..123959656)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123749692..123821593)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene arginine/serine-rich coiled-coil 2 Neighboring gene STARR-positive B cell enhancer ABC_E104 Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene hydrocarboxylic acid receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to kinetochore involved in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RZZ complex ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
is_active_in kinetochore microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinetochore-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042421.1NP_001035886.1  kinetochore-associated protein 1

    See identical proteins and their annotated locations for NP_001035886.1

    Status: VALIDATED

    Source sequence(s)
    AC129582, AK172905, BY010626
    Consensus CDS
    CCDS39274.1
    UniProtKB/Swiss-Prot
    Q6A0B3, Q8C3Y4
    Related
    ENSMUSP00000031366.8, ENSMUST00000031366.12
    Conserved Domains (1) summary
    pfam10493
    Location:15822126
    Rod_C; Rough deal protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123887755..123959656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530253.5XP_006530316.1  kinetochore-associated protein 1 isoform X5

  2. XM_006530252.5XP_006530315.1  kinetochore-associated protein 1 isoform X4

  3. XM_006530250.4XP_006530313.1  kinetochore-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam10493
    Location:15791962
    Rod_C; Rough deal protein C-terminal region
  4. XM_030254330.1XP_030110190.1  kinetochore-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10493
    Location:14271976
    Rod_C; Rough deal protein C-terminal region
  5. XM_006530251.4XP_006530314.1  kinetochore-associated protein 1 isoform X3

    Conserved Domains (1) summary
    pfam10493
    Location:7761325
    Rod_C; Rough deal protein C-terminal region
  6. XM_006530254.2XP_006530317.1  kinetochore-associated protein 1 isoform X6

    Conserved Domains (1) summary
    pfam10493
    Location:6731222
    Rod_C; Rough deal protein C-terminal region