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KNTC1 kinetochore associated 1 [ Homo sapiens (human) ]

Gene ID: 9735, updated on 6-Sep-2022

Summary

Official Symbol
KNTC1provided by HGNC
Official Full Name
kinetochore associated 1provided by HGNC
Primary source
HGNC:HGNC:17255
See related
Ensembl:ENSG00000184445 MIM:607363; AllianceGenome:HGNC:17255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROD
Summary
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 11.5), bone marrow (RPKM 8.4) and 22 other tissues See more
Orthologs
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Genomic context

See KNTC1 in Genome Data Viewer
Location:
12q24.31
Exon count:
67
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (122527249..122626396)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (122522720..122621883)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123011796..123110943)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type containing 8 Neighboring gene arginine and serine rich coiled-coil 2 Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 9902-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36151, KIAA0166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RZZ complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RZZ complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in kinetochore microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore microtubule IC
Inferred by Curator
more info
PubMed 
located_in kinetochore microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinetochore-associated protein 1
Names
Rough Deal homolog, centromere/kinetochore protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046952.1 RefSeqGene

    Range
    5001..104148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014708.6NP_055523.1  kinetochore-associated protein 1

    See identical proteins and their annotated locations for NP_055523.1

    Status: REVIEWED

    Source sequence(s)
    AC026333, AC127002
    Consensus CDS
    CCDS45002.1
    UniProtKB/Swiss-Prot
    B3KSG2, P50748
    Related
    ENSP00000328236.6, ENST00000333479.12
    Conserved Domains (1) summary
    pfam10493
    Location:15832127
    Rod_C; Rough deal protein C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    122527249..122626396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719706.3XP_006719769.1  kinetochore-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006719769.1

    UniProtKB/Swiss-Prot
    B3KSG2, P50748
    Conserved Domains (1) summary
    pfam10493
    Location:15832127
    Rod_C; Rough deal protein C-terminal region
  2. XM_011539027.4XP_011537329.1  kinetochore-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam10493
    Location:15832101
    Rod_C; Rough deal protein C-terminal region
  3. XM_017020254.3XP_016875743.1  kinetochore-associated protein 1 isoform X3

  4. XM_047429917.1XP_047285873.1  kinetochore-associated protein 1 isoform X4

  5. XM_017020255.3XP_016875744.1  kinetochore-associated protein 1 isoform X5

  6. XM_024449285.2XP_024305053.1  kinetochore-associated protein 1 isoform X10

  7. XM_011539029.4XP_011537331.1  kinetochore-associated protein 1 isoform X6

  8. XM_047429918.1XP_047285874.1  kinetochore-associated protein 1 isoform X9

  9. XM_011539030.1XP_011537332.1  kinetochore-associated protein 1 isoform X7

  10. XM_017020257.2XP_016875746.1  kinetochore-associated protein 1 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    122522720..122621883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)