Format

Send to:

Choose Destination

ERV3-1 endogenous retrovirus group 3 member 1, envelope [ Homo sapiens (human) ]

Gene ID: 2086, updated on 12-Aug-2018
Official Symbol
ERV3-1provided by HGNC
Official Full Name
endogenous retrovirus group 3 member 1, envelopeprovided by HGNC
Primary source
HGNC:HGNC:3454
See related
Ensembl:ENSG00000213462 MIM:131170; Vega:OTTHUMG00000165023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERV3; ERVR; envR; ERV-R; HERVR; HERV-R
Summary
This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in adrenal (RPKM 19.4), fat (RPKM 15.6) and 23 other tissues See more
Orthologs
See ERV3-1 in Genome Data Viewer
Location:
7q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (64990355..65006746, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64450733..64467124, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375328 Neighboring gene ERV3-1-ZNF117 readthrough Neighboring gene vomeronasal 1 receptor 43 pseudogene Neighboring gene zinc finger protein 117 Neighboring gene uncharacterized LOC105375330 Neighboring gene RNA, U6 small nuclear 1229, pseudogene Neighboring gene uncharacterized LOC105375329

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough ERV3-1-ZNF117

Readthrough gene: ERV3-1-ZNF117, Included gene: ZNF117

Homology

Clone Names

  • FLJ23884

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Preferred Names
endogenous retrovirus group 3 member 1 Env polyprotein
Names
ERV-R envelope protein
ERV3-1 envelope protein
HERV-R envelope protein
HERV-R_7q21.2 provirus ancestral Env polyprotein
endogenous retroviral sequence 3
endogenous retrovirus group 3, member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007253.3NP_001007254.2  endogenous retrovirus group 3 member 1 Env polyprotein precursor

    See identical proteins and their annotated locations for NP_001007254.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the protein related to endogenous retrovirus.
    Source sequence(s)
    AC073210, AK074464, DA198800
    Consensus CDS
    CCDS47595.1
    UniProtKB/Swiss-Prot
    Q14264
    Related
    ENSP00000391594.1, OTTHUMP00000228206, ENST00000394323.2, OTTHUMT00000381468
    Conserved Domains (1) summary
    cd09850
    Location:521597
    Ebola-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains

RNA

  1. NR_145414.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' exon and lacks the open reading frame found in variant 1.
    Source sequence(s)
    AC073210, AK097499, DA198800
    Related
    ENST00000528878.1
  2. NR_145415.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' exon and lacks the open reading frame found in variant 1.
    Source sequence(s)
    DA198800, F27725
    Related
    ENST00000535538.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    64990355..65006746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center