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Stat1 signal transducer and activator of transcription 1 [ Mus musculus (house mouse) ]

Gene ID: 20846, updated on 20-Feb-2024

Summary

Official Symbol
Stat1provided by MGI
Official Full Name
signal transducer and activator of transcription 1provided by MGI
Primary source
MGI:MGI:103063
See related
Ensembl:ENSMUSG00000026104 AllianceGenome:MGI:103063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010005J02Rik
Summary
Enables DNA-binding transcription factor activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and defense response to other organism. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of macrophage fusion; and response to exogenous dsRNA. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skeletal musculature. Used to study breast cancer and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 23.3), spleen adult (RPKM 19.5) and 28 other tissues See more
Orthologs
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Genomic context

See Stat1 in Genome Data Viewer
Location:
1 C1.1; 1 26.81 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52158588..52201024)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52119438..52161865)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 4 Neighboring gene STARR-seq mESC enhancer starr_00894 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10010 Neighboring gene predicted gene, 31812 Neighboring gene STARR-positive B cell enhancer ABC_E3272 Neighboring gene STARR-positive B cell enhancer ABC_E3273 Neighboring gene transmembrane protein 209 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7722 Neighboring gene glutaminase Neighboring gene STARR-positive B cell enhancer ABC_E1992 Neighboring gene predicted gene, 31867

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-27-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-9-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation by virus of viral protein levels in host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of macrophage fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in renal tubule development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to type I interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in type II interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ISGF3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal transducer and activator of transcription 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205313.1NP_001192242.1  signal transducer and activator of transcription 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC123752, AK046517, BC042551, BX513160
    Consensus CDS
    CCDS78581.1
    UniProtKB/TrEMBL
    A0A087WSP5, Q8C8M3
    Related
    ENSMUSP00000141132.2, ENSMUST00000186057.7
    Conserved Domains (5) summary
    cd10372
    Location:563713
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:139315
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:317572
    STAT_bind; STAT protein, DNA binding domain
    pfam12162
    Location:721745
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  2. NM_001205314.1NP_001192243.1  signal transducer and activator of transcription 1 isoform 2

    See identical proteins and their annotated locations for NP_001192243.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2, 3, and 4 encode the same isoform.
    Source sequence(s)
    AK039458, AK084855, BC042551, BX513160
    Consensus CDS
    CCDS56628.1
    UniProtKB/TrEMBL
    E9QK78, Q3TW11, Q8C3V4, Q9D323
    Related
    ENSMUSP00000140875.2, ENSMUST00000186857.7
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:715739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  3. NM_001357627.1NP_001344556.1  signal transducer and activator of transcription 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123752
    Consensus CDS
    CCDS56628.1
    UniProtKB/TrEMBL
    E9QK78, Q3TW11, Q8C3V4, Q9D323
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:715739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  4. NM_009283.4NP_033309.3  signal transducer and activator of transcription 1 isoform 2

    See identical proteins and their annotated locations for NP_033309.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2, 3, and 4 encode the same isoform.
    Source sequence(s)
    AC123752, AK039458, AK082706, BC042551, BX513160
    Consensus CDS
    CCDS56628.1
    UniProtKB/TrEMBL
    E9QK78, Q3TW11, Q8C3V4, Q9D323
    Related
    ENSMUSP00000066743.8, ENSMUST00000070968.14
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:715739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52158588..52201024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163078.1XP_036018971.1  signal transducer and activator of transcription 1 isoform X2

    UniProtKB/TrEMBL
    Q3TW11, Q8C497, Q99K94, Q9D323
    Related
    ENSMUSP00000140518.2, ENSMUST00000186574.7
    Conserved Domains (4) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
  2. XM_017319463.3XP_017174952.1  signal transducer and activator of transcription 1 isoform X1

    UniProtKB/TrEMBL
    E9QK78, Q3TW11, Q8C3V4, Q9D323
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:715739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  3. XM_030252467.2XP_030108327.1  signal transducer and activator of transcription 1 isoform X1

    UniProtKB/TrEMBL
    E9QK78, Q3TW11, Q8C3V4, Q9D323
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:715739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  4. XM_017319464.3XP_017174953.1  signal transducer and activator of transcription 1 isoform X1

    UniProtKB/TrEMBL
    E9QK78, Q3TW11, Q8C3V4, Q9D323
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:715739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain

RNA

  1. XR_003954297.2 RNA Sequence

  2. XR_003954298.2 RNA Sequence