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STAT1 signal transducer and activator of transcription 1 [ Homo sapiens (human) ]

Gene ID: 6772, updated on 26-Jul-2021

Summary

Official Symbol
STAT1provided by HGNC
Official Full Name
signal transducer and activator of transcription 1provided by HGNC
Primary source
HGNC:HGNC:11362
See related
Ensembl:ENSG00000115415 MIM:600555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91
Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in lymph node (RPKM 79.1), appendix (RPKM 72.6) and 25 other tissues See more
Orthologs
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Genomic context

See STAT1 in Genome Data Viewer
Location:
2q32.2
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (190968989..191014197, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (191833875..191878897, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr2.5899 Neighboring gene glutaminase Neighboring gene RAB1A pseudogene 1 Neighboring gene uncharacterized LOC107985785 Neighboring gene STAT4 antisense RNA 1 Neighboring gene signal transducer and activator of transcription 4 Neighboring gene RNA, U6 small nuclear 959, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Immunodeficiency 31a
MedGen: C4013950 OMIM: 614892 GeneReviews: Not available
Compare labs
Immunodeficiency 31C
MedGen: C3279990 OMIM: 614162 GeneReviews: Not available
Compare labs
Mycobacterial and viral infections, susceptibility to, autosomal recessive
MedGen: C3151088 OMIM: 613796 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2013-09-18)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2013-09-18)

ClinGen Genome Curation Page

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection upregulates basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages PubMed
HIV/tuberculosis coinfection upregulates STAT1 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only) PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) upregulates STAT1 expression at 18 hours post-treatment PubMed
env HIV-1 gp120 activates both STAT1 and STAT2 in primary human monocyte-derived dendritic cells PubMed
env Signal transducer and activator of transcription factor 1 (STAT1) partially regulates HIV-1 gp120/HCV E2-induced caspase 3 activity PubMed
Nef nef HIV-1 Nef-induced tyrosine-hyperphosphorylation of STAT1 is inhibited by the presence of retinoic acid in monocyte-derived DCs PubMed
nef TRAF2 and TRAF6 proteins are required for the HIV-1 Nef-induced tyrosine phosphorylation of STAT1 and STAT2 proteins. Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation PubMed
nef HIV-1 Nef induces phosphorylation of STAT1 in M2-type macrophages PubMed
nef HIV-1 Nef specifically activates both alpha and beta isoforms of the signal transducer and activator of transcription 1 (STAT1) in human monocyte-derived macrophages (MDMs) PubMed
Tat tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia PubMed
tat HIV-1 and the viral protein Tat modulate the expression of signal transducer and activator of transcription 1, 91kDa (STAT1) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including STAT-1 (p91 and p84), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
tat HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation PubMed
tat HIV-1 Tat impairs the IFNgamma-receptor signaling pathway, in primary human monocytes, at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity PubMed
tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
tat HIV-1 Tat represses transcription of the LMP2 gene by competing with STAT1 (signal transducer and activator of transcription 1) for binding to IRF-1 (interferon-regulatory factor-1) at the LMP2 promoter PubMed
Vpr vpr HIV-1 Vpr induces the phosphorylation of STAT1 at tyrosine 701 and upregulates the expression of STAT1 in human monocyte-derived macrophages PubMed
vpr HIV-1 Vpr enhances TNF-alpha production in LPS-stimulated dendritic cells (DC). Vpr-induced TNF-alpha production in DC is through STAT1 activation PubMed
Vpu vpu The expression of STAT1 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed
matrix gag HIV-1 MA recruits STAT1 to the LXR promoter region containing the STAT responsive sequence TTCAGGGAA; STAT1 mediates upregulation of NR1H3 (LXR-alpha) gene expression PubMed
gag HIV-1 MA increases phosphorylation of STAT1 PubMed
gag HIV-1 MA natural variant S75X upregulates the expression of STAT1 and STAT3, and induces phosphorylation of STAT1 at position S727 and STAT3 at position Y705 in Epstein-Barr virus (EBV)-infected B-lymphocytes PubMed
gag Treatment of human stellate cells with HIV-1 MA induces phosphorylation of STAT1 and STAT3 proteins PubMed
gag Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686B04100

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding HDA PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in blood circulation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interferon-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interferon-gamma-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interferon-gamma-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in interleukin-27-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage derived foam cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in metanephric mesenchymal cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in metanephric mesenchymal cell proliferation involved in metanephros development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation by virus of viral protein levels in host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of metanephric nephron tubule epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of defense response to virus by host IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in renal tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to cytokine ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to drug IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interferon-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to peptide hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in type I interferon signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in type I interferon signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in type I interferon signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
signal transducer and activator of transcription 1-alpha/beta
Names
signal transducer and activator of transcription 1, 91kD
signal transducer and activator of transcription 1, 91kDa
transcription factor ISGF-3 components p91/p84

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008294.1 RefSeqGene

    Range
    5001..50215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_111

mRNA and Protein(s)

  1. NM_001384880.1NP_001371809.1  signal transducer and activator of transcription 1-alpha/beta isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:537687
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cl28920
    Location:317457
    STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
    pfam12162
    Location:695719
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  2. NM_001384881.1NP_001371810.1  signal transducer and activator of transcription 1-alpha/beta isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:559709
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:4123
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:140315
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:319479
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:717741
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  3. NM_001384882.1NP_001371811.1  signal transducer and activator of transcription 1-alpha/beta isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Related
    ENSP00000501145.1, ENST00000673942.1
    Conserved Domains (5) summary
    cd10372
    Location:555705
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317475
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:713737
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  4. NM_001384883.1NP_001371812.1  signal transducer and activator of transcription 1-alpha/beta isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:524674
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    cd16845
    Location:284444
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cl28921
    Location:62280
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12162
    Location:682706
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    pfam02865
    Location:2120
    STAT_int; STAT protein, protein interaction domain
  5. NM_001384884.1NP_001371813.1  signal transducer and activator of transcription 1-alpha/beta isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (4) summary
    smart00964
    Location:4123
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:140315
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:319479
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cl15255
    Location:559655
    SH2; Src homology 2 (SH2) domain
  6. NM_001384885.1NP_001371814.1  signal transducer and activator of transcription 1-alpha/beta isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:504654
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16845
    Location:264424
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cl28921
    Location:138261
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12162
    Location:662686
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  7. NM_001384886.1NP_001371815.1  signal transducer and activator of transcription 1-alpha/beta isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:557715
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:723747
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  8. NM_001384887.1NP_001371816.1  signal transducer and activator of transcription 1-alpha/beta isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:526676
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cl28920
    Location:315446
    STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
    pfam12162
    Location:684708
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  9. NM_001384888.1NP_001371817.1  signal transducer and activator of transcription 1-alpha/beta isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:547697
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317467
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:705729
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  10. NM_001384889.1NP_001371818.1  signal transducer and activator of transcription 1-alpha/beta isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:713735
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  11. NM_001384890.1NP_001371819.1  signal transducer and activator of transcription 1-alpha/beta isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:527677
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:124283
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:287447
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:685709
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  12. NM_001384891.1NP_001371820.1  signal transducer and activator of transcription 1-alpha/beta isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC067945
    Conserved Domains (5) summary
    cd10372
    Location:569719
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2133
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:150325
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:329489
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:727751
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  13. NM_007315.4NP_009330.1  signal transducer and activator of transcription 1-alpha/beta isoform alpha

    See identical proteins and their annotated locations for NP_009330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) encodes isoform alpha.
    Source sequence(s)
    AI992149, AK292604, AK315002, BU738296, CN410740, CR749636, CR998778, EB385742
    Consensus CDS
    CCDS2309.1
    UniProtKB/Swiss-Prot
    P42224
    Related
    ENSP00000354394.4, ENST00000361099.8
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:715739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
  14. NM_139266.3NP_644671.1  signal transducer and activator of transcription 1-alpha/beta isoform beta

    See identical proteins and their annotated locations for NP_644671.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) is different in its 3' coding region and UTR compared to variant alpha. It encodes a protein (isoform beta) with a shorter C-terminus, when compared to isoform alpha.
    Source sequence(s)
    BX400908, CR749636, CR998778
    Consensus CDS
    CCDS42793.1
    UniProtKB/Swiss-Prot
    P42224
    Related
    ENSP00000376136.3, ENST00000392322.7
    Conserved Domains (4) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:139315
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:317566
    STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    190968989..191014197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712718.1XP_006712781.1  signal transducer and activator of transcription 1-alpha/beta isoform X2

    See identical proteins and their annotated locations for XP_006712781.1

    UniProtKB/Swiss-Prot
    P42224
    Related
    ENSP00000438703.2, ENST00000540176.6
    Conserved Domains (5) summary
    cd10372
    Location:557707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2121
    STAT_int; STAT protein, protein interaction domain
    cd16851
    Location:138313
    STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    cd16845
    Location:317477
    STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    pfam12162
    Location:715739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain

RNA

  1. XR_001738915.2 RNA Sequence

    Related
    ENST00000673734.1
  2. XR_001738914.2 RNA Sequence

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