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Znrf4 zinc and ring finger 4 [ Mus musculus (house mouse) ]

Gene ID: 20834, updated on 1-Mar-2024

Summary

Official Symbol
Znrf4provided by MGI
Official Full Name
zinc and ring finger 4provided by MGI
Primary source
MGI:MGI:1341258
See related
Ensembl:ENSMUSG00000044526 AllianceGenome:MGI:1341258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
spzn; Ssrzf1; 1700094M01Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human ZNRF4 (zinc and ring finger 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Znrf4 in Genome Data Viewer
Location:
17 D; 17 29.37 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56818248..56819483, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56511248..56512483, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33211 Neighboring gene STARR-positive B cell enhancer ABC_E10963 Neighboring gene predicted gene, 33258 Neighboring gene TINCR ubiquitin domain containing Neighboring gene scaffold attachment factor B2

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZNRF4
Names
RING-type E3 ubiquitin transferase ZNRF4
sperizin
spermatid specific RING zinc finger 1
zinc/RING finger protein 4
NP_035613.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011483.2NP_035613.2  E3 ubiquitin-protein ligase ZNRF4 precursor

    See identical proteins and their annotated locations for NP_035613.2

    Status: VALIDATED

    Source sequence(s)
    AK005843, BY104804
    Consensus CDS
    CCDS28906.1
    UniProtKB/Swiss-Prot
    Q9DAH2, Q9WTN2
    Related
    ENSMUSP00000059715.3, ENSMUST00000052211.4
    Conserved Domains (2) summary
    cd02123
    Location:19156
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    pfam13639
    Location:207252
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56818248..56819483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)