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ZNRF4 zinc and ring finger 4 [ Homo sapiens (human) ]

Gene ID: 148066, updated on 23-Nov-2021

Summary

Official Symbol
ZNRF4provided by HGNC
Official Full Name
zinc and ring finger 4provided by HGNC
Primary source
HGNC:HGNC:17726
See related
Ensembl:ENSG00000105428 MIM:612063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
spzn; RNF204; Ssrzf1; SPERIZIN
Orthologs
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Genomic context

See ZNRF4 in Genome Data Viewer
Location:
19p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (5455417..5456856)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5455428..5456867)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type S Neighboring gene uncharacterized LOC105372252 Neighboring gene Sharpr-MPRA regulatory region 11104 Neighboring gene TINCR ubiquitin domain containing Neighboring gene SNRPE pseudogene 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZNRF4
Names
RING finger protein 204
RING-type E3 ubiquitin transferase ZNRF4
nixin
zinc/RING finger protein 4
NP_859061.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181710.4NP_859061.3  E3 ubiquitin-protein ligase ZNRF4 precursor

    See identical proteins and their annotated locations for NP_859061.3

    Status: VALIDATED

    Source sequence(s)
    AC005764
    Consensus CDS
    CCDS42475.1
    UniProtKB/Swiss-Prot
    Q8WWF5
    Related
    ENSP00000222033.4, ENST00000222033.6
    Conserved Domains (2) summary
    cd02123
    Location:86244
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    pfam13639
    Location:307352
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    5455417..5456856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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