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ZNRF4 zinc and ring finger 4 [ Homo sapiens (human) ]

Gene ID: 148066, updated on 22-Sep-2022

Summary

Official Symbol
ZNRF4provided by HGNC
Official Full Name
zinc and ring finger 4provided by HGNC
Primary source
HGNC:HGNC:17726
See related
Ensembl:ENSG00000105428 MIM:612063; AllianceGenome:HGNC:17726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
spzn; RNF204; Ssrzf1; SPERIZIN
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See ZNRF4 in Genome Data Viewer
Location:
19p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5455417..5456856)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5442067..5443506)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5455428..5456867)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type S Neighboring gene uncharacterized LOC105372252 Neighboring gene Sharpr-MPRA regulatory region 11104 Neighboring gene uncharacterized LOC124904622 Neighboring gene TINCR ubiquitin domain containing

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZNRF4
Names
RING finger protein 204
RING-type E3 ubiquitin transferase ZNRF4
nixin
zinc/RING finger protein 4
NP_859061.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181710.4NP_859061.3  E3 ubiquitin-protein ligase ZNRF4 precursor

    See identical proteins and their annotated locations for NP_859061.3

    Status: VALIDATED

    Source sequence(s)
    AC005764
    Consensus CDS
    CCDS42475.1
    UniProtKB/Swiss-Prot
    O75866, Q8WWF5
    Related
    ENSP00000222033.4, ENST00000222033.6
    Conserved Domains (2) summary
    cd02123
    Location:86244
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    pfam13639
    Location:307352
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    5455417..5456856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    5442067..5443506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)