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Btla B and T lymphocyte associated [ Mus musculus (house mouse) ]

Gene ID: 208154, updated on 12-May-2024

Summary

Official Symbol
Btlaprovided by MGI
Official Full Name
B and T lymphocyte associatedprovided by MGI
Primary source
MGI:MGI:2658978
See related
Ensembl:ENSMUSG00000052013 AllianceGenome:MGI:2658978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630002H24
Summary
Enables signaling receptor activity. Acts upstream of or within immune response-regulating cell surface receptor signaling pathway; negative regulation of B cell proliferation; and negative regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is integral component of plasma membrane. Orthologous to human BTLA (B and T lymphocyte associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 9.3), mammary gland adult (RPKM 3.5) and 3 other tissues See more
Orthologs
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Genomic context

Location:
16 B5; 16 29.52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45043121..45073258)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45223705..45252895)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene autophagy related 3 Neighboring gene STARR-positive B cell enhancer ABC_E1925 Neighboring gene 40S ribosomal protein S24-like Neighboring gene STARR-seq mESC enhancer starr_40914 Neighboring gene STARR-positive B cell enhancer ABC_E8910 Neighboring gene STARR-positive B cell enhancer ABC_E11614 Neighboring gene STARR-seq mESC enhancer starr_40915 Neighboring gene STARR-seq mESC enhancer starr_40916 Neighboring gene STARR-seq mESC enhancer starr_40917 Neighboring gene predicted gene, 30636 Neighboring gene STARR-positive B cell enhancer ABC_E7454 Neighboring gene predicted gene, 30760

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124217, MGC124218

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
B- and T-lymphocyte attenuator
Names
B- and T-lymphocyte-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037719.2NP_001032808.2  B- and T-lymphocyte attenuator isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK041334, BB123968, BC108964
    Consensus CDS
    CCDS28195.1
    UniProtKB/Swiss-Prot
    Q7TSA3
    UniProtKB/TrEMBL
    E9QNY6
    Related
    ENSMUSP00000067877.5, ENSMUST00000063654.6
    Conserved Domains (2) summary
    smart00410
    Location:50142
    IG_like; Immunoglobulin like
    cl11960
    Location:97143
    Ig; Immunoglobulin domain
  2. NM_177584.3NP_808252.1  B- and T-lymphocyte attenuator isoform 2 precursor

    See identical proteins and their annotated locations for NP_808252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK041334, BB123968
    Consensus CDS
    CCDS28196.1
    UniProtKB/Swiss-Prot
    Q7TSA3
    UniProtKB/TrEMBL
    A0A0R4J1A0
    Related
    ENSMUSP00000099866.4, ENSMUST00000102802.10
    Conserved Domains (2) summary
    smart00410
    Location:50142
    IG_like; Immunoglobulin like
    cl11960
    Location:97143
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45043121..45073258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159833.1XP_036015726.1  B- and T-lymphocyte attenuator isoform X3

    Conserved Domains (2) summary
    cd00096
    Location:4247
    Ig; Ig strand A [structural motif]
    cl11960
    Location:40143
    Ig; Immunoglobulin domain
  2. XM_036159834.1XP_036015727.1  B- and T-lymphocyte attenuator isoform X3

    Conserved Domains (2) summary
    cd00096
    Location:4247
    Ig; Ig strand A [structural motif]
    cl11960
    Location:40143
    Ig; Immunoglobulin domain
  3. XM_006521907.5XP_006521970.1  B- and T-lymphocyte attenuator isoform X1

  4. XM_006521908.5XP_006521971.1  B- and T-lymphocyte attenuator isoform X2