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Yeats2 YEATS domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 208146, updated on 30-Apr-2024

Summary

Official Symbol
Yeats2provided by MGI
Official Full Name
YEATS domain containing 2provided by MGI
Primary source
MGI:MGI:2447762
See related
Ensembl:ENSMUSG00000041215 AllianceGenome:MGI:2447762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1197
Summary
Predicted to enable TBP-class protein binding activity; histone binding activity; and modification-dependent protein binding activity. Predicted to be involved in histone H3 acetylation and negative regulation of transcription by RNA polymerase II. Located in mitotic spindle and nucleus. Part of ATAC complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 38.3), CNS E14 (RPKM 32.8) and 25 other tissues See more
Orthologs
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Genomic context

See Yeats2 in Genome Data Viewer
Location:
16 A3; 16 12.37 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19959803..20051323)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20141053..20232573)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40308 Neighboring gene kelch-like 6 Neighboring gene STARR-seq mESC enhancer starr_40309 Neighboring gene STARR-positive B cell enhancer ABC_E2456 Neighboring gene STARR-positive B cell enhancer ABC_E1183 Neighboring gene kelch-like 24 Neighboring gene STARR-seq mESC enhancer starr_40314 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40316 Neighboring gene predicted gene, 41431 Neighboring gene MAP6 domain containing 1 Neighboring gene predicted gene, 49566

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
 
enables modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ATAC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
YEATS domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033237.2NP_001028409.2  YEATS domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an exon found in transcript variant 1, which results in translation initiation from an in-frame downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK160791, BC150944, BU055428, CB182287
    Consensus CDS
    CCDS28043.1
    UniProtKB/TrEMBL
    B9EKJ4
    Related
    ENSMUSP00000087506.5, ENSMUST00000090052.11
    Conserved Domains (2) summary
    PRK07003
    Location:8341070
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:156279
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  2. NM_001145930.1NP_001139402.1  YEATS domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001139402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK160791, AK165933, BC150944, BU055428, CB182287
    Consensus CDS
    CCDS49790.1
    UniProtKB/Swiss-Prot
    Q3TUF7, Q6PGF8, Q80TI2, Q8CG86
    UniProtKB/TrEMBL
    A0A338P697
    Related
    ENSMUSP00000111222.3, ENSMUST00000115560.4
    Conserved Domains (2) summary
    PRK07003
    Location:8871123
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:209332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  3. NM_001145931.1NP_001139403.1  YEATS domain-containing protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate segment at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA138143, AC120150, AK165933, BU055428
    Conserved Domains (1) summary
    pfam03366
    Location:232309
    YEATS; YEATS family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    19959803..20051323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521903.4XP_006521966.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:8841120
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:206329
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  2. XM_036159831.1XP_036015724.1  YEATS domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:8841120
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:206329
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  3. XM_006521904.3XP_006521967.1  YEATS domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:8871123
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:209332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  4. XM_006521905.3XP_006521968.1  YEATS domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:7901026
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:209332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  5. XM_030249018.1XP_030104878.1  YEATS domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    B9EKJ4
    Related
    ENSMUSP00000155892.2, ENSMUST00000232019.2
    Conserved Domains (2) summary
    PRK07003
    Location:8311067
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:153276
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  6. XM_006521902.5XP_006521965.1  YEATS domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006521965.1

    UniProtKB/Swiss-Prot
    Q3TUF7, Q6PGF8, Q80TI2, Q8CG86
    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:8871123
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:209332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  7. XM_030249017.1XP_030104877.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:8841120
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:206329
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12
  8. XM_036159832.1XP_036015725.1  YEATS domain-containing protein 2 isoform X8

    Conserved Domains (1) summary
    PRK07003
    Location:432668
    PRK07003; DNA polymerase III subunit gamma/tau
  9. XM_006521906.5XP_006521969.1  YEATS domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    B9EKJ4
    Conserved Domains (1) summary
    PRK07003
    Location:619855
    PRK07003; DNA polymerase III subunit gamma/tau

RNA

  1. XR_001781806.3 RNA Sequence

  2. XR_384540.4 RNA Sequence

    Related
    ENSMUST00000232338.2
  3. XR_384538.4 RNA Sequence

  4. XR_004939174.1 RNA Sequence

  5. XR_001781807.2 RNA Sequence

  6. XR_384537.4 RNA Sequence