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YEATS2 YEATS domain containing 2 [ Homo sapiens (human) ]

Gene ID: 55689, updated on 22-Sep-2022

Summary

Official Symbol
YEATS2provided by HGNC
Official Full Name
YEATS domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25489
See related
Ensembl:ENSG00000163872 MIM:613373; AllianceGenome:HGNC:25489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAME4
Summary
Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in ovary (RPKM 7.4), brain (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

See YEATS2 in Genome Data Viewer
Location:
3q27.1
Exon count:
36
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (183697797..183812624)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (186507277..186622124)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183415585..183530412)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374248 Neighboring gene uncharacterized LOC107986162 Neighboring gene kelch like family member 24 Neighboring gene YEATS2 antisense RNA 1 Neighboring gene MAP6 domain containing 1 Neighboring gene presenilin associated rhomboid like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10201, FLJ12841, FLJ13308, FLJ33401, FLJ34335, KIAA1197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables TBP-class protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3-K14 acetylation IC
Inferred by Curator
more info
 
involved_in histone H3-K14 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IC
Inferred by Curator
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IC
Inferred by Curator
more info
 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell division IC
Inferred by Curator
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of embryonic development IC
Inferred by Curator
more info
 
involved_in regulation of histone deacetylation IC
Inferred by Curator
more info
 
involved_in regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of tubulin deacetylation IC
Inferred by Curator
more info
 
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATAC complex IC
Inferred by Curator
more info
 
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle IC
Inferred by Curator
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
YEATS domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054747.1 RefSeqGene

    Range
    5001..119828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351369.2NP_001338298.1  YEATS domain-containing protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC068769, AC131160
    Consensus CDS
    CCDS43175.1
    UniProtKB/Swiss-Prot
    Q9NW96
    Conserved Domains (1) summary
    pfam03366
    Location:231310
    YEATS; YEATS family
  2. NM_001351370.2NP_001338299.1  YEATS domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC068769, AC131160
    Conserved Domains (1) summary
    pfam03366
    Location:231310
    YEATS; YEATS family
  3. NM_001351371.2NP_001338300.1  YEATS domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC068769
    Conserved Domains (1) summary
    pfam03366
    Location:231310
    YEATS; YEATS family
  4. NM_018023.5NP_060493.3  YEATS domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_060493.3

    Status: REVIEWED

    Source sequence(s)
    AC068769, BC082270, BC150273, CA416892
    Consensus CDS
    CCDS43175.1
    UniProtKB/Swiss-Prot
    Q9NW96, Q9ULM3
    Related
    ENSP00000306983.5, ENST00000305135.10
    Conserved Domains (1) summary
    pfam03366
    Location:231310
    YEATS; YEATS family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    183697797..183812624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448527.1XP_047304483.1  YEATS domain-containing protein 2 isoform X1

  2. XM_047448528.1XP_047304484.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9NW96
  3. XM_011512965.2XP_011511267.1  YEATS domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    cl19881
    Location:217256
    YEATS; YEATS family
  4. XM_047448531.1XP_047304487.1  YEATS domain-containing protein 2 isoform X5

  5. XM_047448534.1XP_047304490.1  YEATS domain-containing protein 2 isoform X6

  6. XM_047448535.1XP_047304491.1  YEATS domain-containing protein 2 isoform X7

  7. XM_011512966.2XP_011511268.1  YEATS domain-containing protein 2 isoform X8

    Conserved Domains (1) summary
    pfam03366
    Location:231310
    YEATS; YEATS family
  8. XM_047448542.1XP_047304498.1  YEATS domain-containing protein 2 isoform X11

  9. XM_005247598.6XP_005247655.1  YEATS domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005247655.1

    Conserved Domains (1) summary
    pfam03366
    Location:231310
    YEATS; YEATS family
  10. XM_017006810.2XP_016862299.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9NW96, Q9ULM3
    Conserved Domains (1) summary
    pfam03366
    Location:231310
    YEATS; YEATS family
  11. XM_047448530.1XP_047304486.1  YEATS domain-containing protein 2 isoform X4

  12. XM_047448532.1XP_047304488.1  YEATS domain-containing protein 2 isoform X5

  13. XM_047448536.1XP_047304492.1  YEATS domain-containing protein 2 isoform X8

  14. XM_047448538.1XP_047304494.1  YEATS domain-containing protein 2 isoform X9

  15. XM_047448533.1XP_047304489.1  YEATS domain-containing protein 2 isoform X5

  16. XM_047448537.1XP_047304493.1  YEATS domain-containing protein 2 isoform X8

  17. XM_047448540.1XP_047304496.1  YEATS domain-containing protein 2 isoform X9

  18. XM_017006811.3XP_016862300.1  YEATS domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam03366
    Location:178257
    YEATS; YEATS family
  19. XM_047448541.1XP_047304497.1  YEATS domain-containing protein 2 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    186507277..186622124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)