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YEATS2 YEATS domain containing 2 [ Homo sapiens (human) ]

Gene ID: 55689, updated on 25-Nov-2025
Official Symbol
YEATS2provided by HGNC
Official Full Name
YEATS domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25489
See related
Ensembl:ENSG00000163872 MIM:613373; AllianceGenome:HGNC:25489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAME4
Summary
Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in ovary (RPKM 7.4), brain (RPKM 7.1) and 25 other tissues See more
Orthologs
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See YEATS2 in Genome Data Viewer
Location:
3q27.1
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (183697797..183812624)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (186507277..186622124)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183415585..183530412)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374248 Neighboring gene uncharacterized LOC107986162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14946 Neighboring gene kelch like family member 24 Neighboring gene NANOG hESC enhancer GRCh37_chr3:183384502-183385010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14947 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:183527422-183528621 Neighboring gene YEATS2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:183535409-183536020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14950 Neighboring gene MAP6 domain containing 1 Neighboring gene presenilin associated rhomboid like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14951

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival. Sheng H, et al. Cell Biol Toxicol, 2023 Jun. PMID 34686948
  2. TTTCA repeat insertions in an intron of YEATS2 in benign adult familial myoclonic epilepsy type 4. Yeetong P, et al. Brain, 2019 Nov 1. PMID 31539032
  3. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Mi W, et al. Nat Commun, 2017 Oct 20. PMID 29057918, Free PMC Article
  4. YEATS2 is a selective histone crotonylation reader. Zhao D, et al. Cell Res, 2016 May. PMID 27103431, Free PMC Article
  5. YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma. Sha T, et al. Bioengineered, 2021 Dec. PMID 34587874, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth.
    Title: Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth.
  2. YEATS2 regulates the activation of TAK1/NF-kappaB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.
    Title: YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.
  3. YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma.
    Title: YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma.
  4. YEATS2 is a target of HIF1alpha and promotes pancreatic cancer cell proliferation and migration.
    Title: YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.
  5. our findings suggest that benign adult familial myoclonic epilepsy type 4 is caused by the insertions of the intronic TTTCA repeats in YEATS2
    Title: TTTCA repeat insertions in an intron of YEATS2 in benign adult familial myoclonic epilepsy type 4.
  6. YEATS2 is a selective histone crotonylation reader.
    Title: YEATS2 is a selective histone crotonylation reader.
  7. YEATS2 gene is highly amplified in human non-small cell lung cancer (NSCLC) and is required for cancer cell growth and survival
    Title: YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Epilepsy, familial adult myoclonic, 4
MedGen: C3554560 OMIM: 615127 GeneReviews: Not available
not available

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10201, FLJ12841, FLJ13308, FLJ33401, FLJ34335, KIAA1197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables TBP-class protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ATAC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex IEA
Inferred from Electronic Annotation
more info
  
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
YEATS domain-containing protein 2
NP_001338298.1

Length

  • 1422
NP_001338299.1

Length

  • 1423
NP_001338300.1

Length

  • 1033
NP_060493.3

Length

  • 1422

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054747.1 RefSeqGene

    Range
    5001..119828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351369.2 → NP_001338298.1  YEATS domain-containing protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC068769, AC131160
    Consensus CDS
    CCDS43175.1
    UniProtKB/Swiss-Prot
    A7E2B9, D3DNS9, Q641P6, Q9NW96, Q9ULM3
    Conserved Domains (1) summary
    pfam03366
    Location:231 → 310
    YEATS; YEATS family

  2. NM_001351370.2 → NP_001338299.1  YEATS domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC068769, AC131160
    Related
    ENSP00000554791.1, ENST00000884732.1
    Conserved Domains (1) summary
    pfam03366
    Location:231 → 310
    YEATS; YEATS family

  3. NM_001351371.2 → NP_001338300.1  YEATS domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC068769
    Conserved Domains (1) summary
    pfam03366
    Location:231 → 310
    YEATS; YEATS family

  4. NM_018023.5 → NP_060493.3  YEATS domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_060493.3

    Status: REVIEWED

    Source sequence(s)
    AC068769, BC082270, BC150273, CA416892
    Consensus CDS
    CCDS43175.1
    UniProtKB/Swiss-Prot
    A7E2B9, D3DNS9, Q641P6, Q9NW96, Q9ULM3
    Related
    ENSP00000306983.5, ENST00000305135.10
    Conserved Domains (1) summary
    pfam03366
    Location:231 → 310
    YEATS; YEATS family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    183697797..183812624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448527.1 → XP_047304483.1  YEATS domain-containing protein 2 isoform X1

    Related
    ENSP00000554795.1, ENST00000884736.1

  2. XM_047448528.1 → XP_047304484.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A7E2B9, D3DNS9, Q641P6, Q9NW96, Q9ULM3
    Related
    ENSP00000597123.1, ENST00000927064.1

  3. XM_011512965.2 → XP_011511267.1  YEATS domain-containing protein 2 isoform X4

    Related
    ENSP00000597122.1, ENST00000927063.1
    Conserved Domains (1) summary
    cl19881
    Location:217 → 256
    YEATS; YEATS family

  4. XM_047448531.1 → XP_047304487.1  YEATS domain-containing protein 2 isoform X5

    Related
    ENSP00000597120.1, ENST00000927061.1

  5. XM_047448534.1 → XP_047304490.1  YEATS domain-containing protein 2 isoform X6

  6. XM_047448535.1 → XP_047304491.1  YEATS domain-containing protein 2 isoform X7

  7. XM_011512966.2 → XP_011511268.1  YEATS domain-containing protein 2 isoform X8

    Conserved Domains (1) summary
    pfam03366
    Location:231 → 310
    YEATS; YEATS family

  8. XM_047448542.1 → XP_047304498.1  YEATS domain-containing protein 2 isoform X11

  9. XM_005247598.6 → XP_005247655.1  YEATS domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005247655.1

    Related
    ENSP00000597125.1, ENST00000927066.1
    Conserved Domains (1) summary
    pfam03366
    Location:231 → 310
    YEATS; YEATS family

  10. XM_017006810.2 → XP_016862299.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A7E2B9, D3DNS9, Q641P6, Q9NW96, Q9ULM3
    Related
    ENSP00000554796.1, ENST00000884737.1
    Conserved Domains (1) summary
    pfam03366
    Location:231 → 310
    YEATS; YEATS family

  11. XM_047448530.1 → XP_047304486.1  YEATS domain-containing protein 2 isoform X4

  12. XM_047448532.1 → XP_047304488.1  YEATS domain-containing protein 2 isoform X5

  13. XM_047448536.1 → XP_047304492.1  YEATS domain-containing protein 2 isoform X8

  14. XM_047448538.1 → XP_047304494.1  YEATS domain-containing protein 2 isoform X9

  15. XM_047448533.1 → XP_047304489.1  YEATS domain-containing protein 2 isoform X5

  16. XM_047448537.1 → XP_047304493.1  YEATS domain-containing protein 2 isoform X8

  17. XM_047448540.1 → XP_047304496.1  YEATS domain-containing protein 2 isoform X9

  18. XM_017006811.3 → XP_016862300.1  YEATS domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam03366
    Location:178 → 257
    YEATS; YEATS family

  19. XM_047448541.1 → XP_047304497.1  YEATS domain-containing protein 2 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    186507277..186622124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347198.1 → XP_054203173.1  YEATS domain-containing protein 2 isoform X1

  2. XM_054347200.1 → XP_054203175.1  YEATS domain-containing protein 2 isoform X2

  3. XM_054347202.1 → XP_054203177.1  YEATS domain-containing protein 2 isoform X4

  4. XM_054347204.1 → XP_054203179.1  YEATS domain-containing protein 2 isoform X5

  5. XM_054347207.1 → XP_054203182.1  YEATS domain-containing protein 2 isoform X6

  6. XM_054347208.1 → XP_054203183.1  YEATS domain-containing protein 2 isoform X7

  7. XM_054347209.1 → XP_054203184.1  YEATS domain-containing protein 2 isoform X8

  8. XM_054347215.1 → XP_054203190.1  YEATS domain-containing protein 2 isoform X11

  9. XM_054347197.1 → XP_054203172.1  YEATS domain-containing protein 2 isoform X1

  10. XM_054347199.1 → XP_054203174.1  YEATS domain-containing protein 2 isoform X2

  11. XM_054347212.1 → XP_054203187.1  YEATS domain-containing protein 2 isoform X9

  12. XM_054347210.1 → XP_054203185.1  YEATS domain-containing protein 2 isoform X8

  13. XM_054347203.1 → XP_054203178.1  YEATS domain-containing protein 2 isoform X4

  14. XM_054347205.1 → XP_054203180.1  YEATS domain-containing protein 2 isoform X5

  15. XM_054347206.1 → XP_054203181.1  YEATS domain-containing protein 2 isoform X5

  16. XM_054347211.1 → XP_054203186.1  YEATS domain-containing protein 2 isoform X8

  17. XM_054347213.1 → XP_054203188.1  YEATS domain-containing protein 2 isoform X9

  18. XM_054347201.1 → XP_054203176.1  YEATS domain-containing protein 2 isoform X3

  19. XM_054347214.1 → XP_054203189.1  YEATS domain-containing protein 2 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULM3.2 GenPept UniProtKB/Swiss-Prot:Q9ULM3

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