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Sparc secreted acidic cysteine rich glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 20692, updated on 8-Feb-2024

Summary

Official Symbol
Sparcprovided by MGI
Official Full Name
secreted acidic cysteine rich glycoproteinprovided by MGI
Primary source
MGI:MGI:98373
See related
Ensembl:ENSMUSG00000018593 AllianceGenome:MGI:98373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ON; BM-40
Summary
Enables calcium ion binding activity and extracellular matrix binding activity. Acts upstream of or within several processes, including bone development; cellular response to growth factor stimulus; and pigmentation. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 1043.9), bladder adult (RPKM 893.4) and 22 other tissues See more
Orthologs
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Genomic context

See Sparc in Genome Data Viewer
Location:
11 B1.3; 11 33.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55284985..55310906, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55394159..55420080, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 2 Neighboring gene STARR-seq mESC enhancer starr_29533 Neighboring gene predicted gene, 31842 Neighboring gene STARR-seq mESC enhancer starr_29535 Neighboring gene STARR-seq mESC enhancer starr_29537 Neighboring gene STARR-seq mESC enhancer starr_29542 Neighboring gene STARR-seq mESC enhancer starr_29544 Neighboring gene antioxidant 1 copper chaperone Neighboring gene predicted gene 12235

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SPARC
Names
basement-membrane protein 40
osteonectin
secreted protein acidic and rich in cysteine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290817.1NP_001277746.1  SPARC isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA798908, AK148670, AK161229, BB857564, BE655213, BY781653, CJ132527
    Consensus CDS
    CCDS70189.1
    UniProtKB/TrEMBL
    Q3TXI6, Q5NCU4
    Related
    ENSMUSP00000104486.2, ENSMUST00000108858.8
    Conserved Domains (2) summary
    cd01328
    Location:69150
    FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
    cd16235
    Location:153292
    EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)
  2. NM_009242.5NP_033268.1  SPARC precursor

    See identical proteins and their annotated locations for NP_033268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA798908, AK161229, BB857564, BE655213, BY781653, CJ132527
    Consensus CDS
    CCDS24712.1
    UniProtKB/Swiss-Prot
    P07214
    UniProtKB/TrEMBL
    Q3TXI6, Q5NCU5
    Related
    ENSMUSP00000018737.7, ENSMUST00000018737.13
    Conserved Domains (2) summary
    cd01328
    Location:70151
    FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
    cd16235
    Location:154293
    EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55284985..55310906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)