U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sntb2 syntrophin, basic 2 [ Mus musculus (house mouse) ]

Gene ID: 20650, updated on 5-Mar-2024

Summary

Official Symbol
Sntb2provided by MGI
Official Full Name
syntrophin, basic 2provided by MGI
Primary source
MGI:MGI:101771
See related
Ensembl:ENSMUSG00000041308 AllianceGenome:MGI:101771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SNT3; SNTL; Snt2
Summary
Predicted to enable actin binding activity; calmodulin binding activity; and structural molecule activity. Located in synapse. Orthologous to human SNTB2 (syntrophin beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 9.9), testis adult (RPKM 7.1) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sntb2 in Genome Data Viewer
Location:
8 D3; 8 53.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107662372..107740864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106935740..107014232)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22583 Neighboring gene UTP4 small subunit processome component Neighboring gene ribosomal protein L10, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_22588 Neighboring gene STARR-seq mESC enhancer starr_22589 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:109526496-109526679 Neighboring gene predicted gene, 22085 Neighboring gene STARR-positive B cell enhancer ABC_E3803 Neighboring gene predicted gene 16208 Neighboring gene vacuolar protein sorting 4A Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dystrophin-associated glycoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-2-syntrophin
Names
59 kDa dystrophin-associated protein A1 basic component 2
syntrophin-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368316.1NP_001355245.1  beta-2-syntrophin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123864, AC123868
    Consensus CDS
    CCDS90456.1
    UniProtKB/TrEMBL
    B7ZNU9, Q3V2N5
    Related
    ENSMUSP00000037324.5, ENSMUST00000047425.5
  2. NM_009229.5NP_033255.1  beta-2-syntrophin isoform 2

    See identical proteins and their annotated locations for NP_033255.1

    Status: VALIDATED

    Source sequence(s)
    AC123864, AC123868
    Consensus CDS
    CCDS22642.1
    UniProtKB/Swiss-Prot
    Q61235
    UniProtKB/TrEMBL
    Q3V2N5, Q542S9
    Related
    ENSMUSP00000148684.2, ENSMUST00000212524.2
    Conserved Domains (4) summary
    smart00233
    Location:317417
    PH; Pleckstrin homology domain
    cd00992
    Location:93175
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01258
    Location:224281
    PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
    pfam00169
    Location:306417
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107662372..107740864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)