U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Snai2 snail family zinc finger 2 [ Mus musculus (house mouse) ]

Gene ID: 20583, updated on 7-Apr-2024

Summary

Official Symbol
Snai2provided by MGI
Official Full Name
snail family zinc finger 2provided by MGI
Primary source
MGI:MGI:1096393
See related
Ensembl:ENSMUSG00000022676 AllianceGenome:MGI:1096393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slug; Slugh; Snail2
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including desmosome disassembly; mesenchyme development; and sensory perception of sound. Acts upstream of or within several processes, including animal organ morphogenesis; negative regulation of cell adhesion involved in substrate-bound cell migration; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study Waardenburg syndrome type 2D. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 17.7), mammary gland adult (RPKM 5.5) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Snai2 in Genome Data Viewer
Location:
16 A1; 16 10.07 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (14523716..14527259)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (14705852..14709395)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A630010A05 gene Neighboring gene STARR-seq mESC enhancer starr_40188 Neighboring gene STARR-seq mESC enhancer starr_40189 Neighboring gene STARR-seq mESC enhancer starr_40190 Neighboring gene predicted gene, 57629 Neighboring gene STARR-seq mESC enhancer starr_40191 Neighboring gene STARR-seq mESC enhancer starr_40192 Neighboring gene STARR-seq mESC enhancer starr_40193 Neighboring gene STARR-seq mESC enhancer starr_40194 Neighboring gene STARR-positive B cell enhancer ABC_E5525 Neighboring gene STARR-seq mESC enhancer starr_40195 Neighboring gene predicted gene, 25547 Neighboring gene predicted gene, 33696 Neighboring gene calaxin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to ionizing radiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within_positive_effect chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in desmosome disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in desmosome disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of myeloid cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell adhesion involved in substrate-bound cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vitamin D biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vitamin D receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neural crest cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pigmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell chemotaxis IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of apoptotic process IC
Inferred by Curator
more info
PubMed 
involved_in regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to radiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within substrate-dependent cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of white fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing, spreading of cells TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger protein SNAI2
Names
neural crest transcription factor Slug
protein snail homolog 2
slug, chicken homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011415.3NP_035545.1  zinc finger protein SNAI2

    See identical proteins and their annotated locations for NP_035545.1

    Status: VALIDATED

    Source sequence(s)
    AK133968, BC062164
    Consensus CDS
    CCDS27974.1
    UniProtKB/Swiss-Prot
    O09096, P97469, Q9R211
    UniProtKB/TrEMBL
    Q3UZ96
    Related
    ENSMUSP00000023356.7, ENSMUST00000023356.8
    Conserved Domains (4) summary
    sd00017
    Location:188208
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:131151
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:214236
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:201224
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    14523716..14527259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)