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Slc31a2 solute carrier family 31, member 2 [ Mus musculus (house mouse) ]

Gene ID: 20530, updated on 12-May-2024

Summary

Official Symbol
Slc31a2provided by MGI
Official Full Name
solute carrier family 31, member 2provided by MGI
Primary source
MGI:MGI:1333844
See related
Ensembl:ENSMUSG00000066152 AllianceGenome:MGI:1333844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTR2
Summary
Acts upstream of or within cellular copper ion homeostasis and regulation of copper ion transmembrane transport. Located in late endosome; membrane; and recycling endosome. Is expressed in brain; retina nuclear layer; and urinary system. Orthologous to human SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 27.9), adrenal adult (RPKM 15.7) and 28 other tissues See more
Orthologs
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Genomic context

See Slc31a2 in Genome Data Viewer
Location:
4 B3; 4 33.07 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62198630..62216649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62280393..62298412)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10414 Neighboring gene predicted gene, 30511 Neighboring gene STARR-positive B cell enhancer ABC_E4633 Neighboring gene STARR-seq mESC enhancer starr_10417 Neighboring gene predicted gene, 23148 Neighboring gene FK506 binding protein 15 Neighboring gene STARR-seq mESC enhancer starr_10422 Neighboring gene STARR-positive B cell enhancer ABC_E1277 Neighboring gene STARR-seq mESC enhancer starr_10423 Neighboring gene solute carrier family 31, member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62069546-62069847 Neighboring gene cell division cycle 26

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117640

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables copper ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein SLC31A2
Names
copper transporter 2
probable low affinity copper uptake protein 2
solute carrier family 31 (copper transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290518.1NP_001277447.1  protein SLC31A2 isoform 2

    See identical proteins and their annotated locations for NP_001277447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK015878, BC029183, BY482108
    Consensus CDS
    CCDS71401.1
    UniProtKB/TrEMBL
    Q3U9W6, Q9D524
    Related
    ENSMUSP00000103091.2, ENSMUST00000107467.3
    Conserved Domains (1) summary
    pfam04145
    Location:1133
    Ctr; Ctr copper transporter family
  2. NM_025286.3NP_079562.1  protein SLC31A2 isoform 1

    See identical proteins and their annotated locations for NP_079562.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB853212, BC029183, BY482108
    Consensus CDS
    CCDS18236.1
    UniProtKB/Swiss-Prot
    Q9CPU9
    UniProtKB/TrEMBL
    Q3U9W6, Q4KL43
    Related
    ENSMUSP00000081578.3, ENSMUST00000084530.9
    Conserved Domains (1) summary
    pfam04145
    Location:1135
    Ctr; Ctr copper transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62198630..62216649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537712.2XP_006537775.1  protein SLC31A2 isoform X1

    See identical proteins and their annotated locations for XP_006537775.1

    UniProtKB/TrEMBL
    Q3U9W6, Q9D524
    Related
    ENSMUSP00000103092.2, ENSMUST00000107468.8
    Conserved Domains (1) summary
    pfam04145
    Location:1133
    Ctr; Ctr copper transporter family