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SLC31A2 solute carrier family 31 member 2 [ Homo sapiens (human) ]

Gene ID: 1318, updated on 22-Sep-2022

Summary

Official Symbol
SLC31A2provided by HGNC
Official Full Name
solute carrier family 31 member 2provided by HGNC
Primary source
HGNC:HGNC:11017
See related
Ensembl:ENSG00000136867 MIM:603088; AllianceGenome:HGNC:11017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTR2; COPT2; hCTR2
Summary
Predicted to enable copper ion transmembrane transporter activity. Predicted to be involved in cellular copper ion homeostasis. Predicted to act upstream of or within regulation of copper ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in salivary gland (RPKM 28.8), spleen (RPKM 6.8) and 18 other tissues See more
Orthologs
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Genomic context

See SLC31A2 in Genome Data Viewer
Location:
9q32
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113151007..113164140)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125349843..125362976)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115913287..115926420)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 225 member A Neighboring gene Sharpr-MPRA regulatory region 7760 Neighboring gene Sharpr-MPRA regulatory region 5302 Neighboring gene FKBP prolyl isomerase family member 15 Neighboring gene solute carrier family 31 member 1 Neighboring gene uncharacterized LOC107987119 Neighboring gene cell division cycle 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables copper ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular copper ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in copper ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable low affinity copper uptake protein 2
Names
copper transporter 2
solute carrier family 31 (copper transporter), member 2
solute carrier family 31 (copper transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001860.3NP_001851.1  probable low affinity copper uptake protein 2

    See identical proteins and their annotated locations for NP_001851.1

    Status: VALIDATED

    Source sequence(s)
    AL449105, BP341248, CN480022, U83461
    Consensus CDS
    CCDS6788.1
    UniProtKB/Swiss-Prot
    O15432
    UniProtKB/TrEMBL
    Q53X94
    Related
    ENSP00000259392.3, ENST00000259392.8
    Conserved Domains (1) summary
    pfam04145
    Location:3135
    Ctr; Ctr copper transporter family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    113151007..113164140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    125349843..125362976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)