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Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 [ Mus musculus (house mouse) ]

Gene ID: 20528, updated on 22-Jan-2019

Summary

Official Symbol
Slc2a4provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 4provided by MGI
Primary source
MGI:MGI:95758
See related
Ensembl:ENSMUSG00000018566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GT2; twgy; Glut4; Glut-4
Expression
Biased expression in heart adult (RPKM 161.8), mammary gland adult (RPKM 97.3) and 12 other tissues See more
Orthologs

Genomic context

See Slc2a4 in Genome Data Viewer
Location:
11 B3; 11 42.93 cM
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (69942286..69948217, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69755788..69761692, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box protein 2 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene claudin 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (3)  1 citation

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
D-glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
insulin-responsive glucose:proton symporter activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
amylopectin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose import ISO
Inferred from Sequence Orthology
more info
 
glucose import in response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
glucose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
regulation of synaptic vesicle budding from presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
T-tubule ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
insulin-responsive compartment IDA
Inferred from Direct Assay
more info
PubMed 
insulin-responsive compartment ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
multivesicular body ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynapse ISO
Inferred from Sequence Orthology
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with vesicle ISO
Inferred from Sequence Orthology
more info
 
vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 4
Names
glucose transporter type 4, insulin-responsive

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359114.1NP_001346043.1  solute carrier family 2, facilitated glucose transporter member 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK137607, BY096615, BY226822
    Conserved Domains (1) summary
    pfam00083
    Location:1391
    Sugar_tr; Sugar (and other) transporter
  2. NM_009204.2NP_033230.2  solute carrier family 2, facilitated glucose transporter member 4 isoform 1

    See identical proteins and their annotated locations for NP_033230.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK137607, AL596185
    Consensus CDS
    CCDS36201.1
    UniProtKB/Swiss-Prot
    P14142
    Related
    ENSMUSP00000018710.6, ENSMUST00000018710.12
    Conserved Domains (2) summary
    cd06174
    Location:78447
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:27483
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    69942286..69948217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532653.2XP_006532716.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

    See identical proteins and their annotated locations for XP_006532716.1

    Conserved Domains (1) summary
    pfam00083
    Location:1391
    Sugar_tr; Sugar (and other) transporter
  2. XM_006532655.3XP_006532718.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X2

    See identical proteins and their annotated locations for XP_006532718.1

    Conserved Domains (2) summary
    cd06174
    Location:130290
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:1326
    Sugar_tr; Sugar (and other) transporter
  3. XM_006532654.1XP_006532717.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

    See identical proteins and their annotated locations for XP_006532717.1

    Conserved Domains (1) summary
    pfam00083
    Location:1391
    Sugar_tr; Sugar (and other) transporter

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    46816..52720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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