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SLC2A4 solute carrier family 2 member 4 [ Homo sapiens (human) ]

Gene ID: 6517, updated on 9-Jun-2020

Summary

Official Symbol
SLC2A4provided by HGNC
Official Full Name
solute carrier family 2 member 4provided by HGNC
Primary source
HGNC:HGNC:11009
See related
Ensembl:ENSG00000181856 MIM:138190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT4
Summary
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 32.2), fat (RPKM 24.5) and 6 other tissues See more
Orthologs

Genomic context

See SLC2A4 in Genome Data Viewer
Location:
17p13.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7281718..7288257)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7184986..7191367)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene claudin 7 Neighboring gene Y-box binding protein 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene G protein pathway suppressor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef inhibits GLUT4 fusion with plasma membrane in insulin-stimulated adipocytes, which leads to inhibition of glucose uptake PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-glucose transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
glucose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
amylopectin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to osmotic stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
glucose import NAS
Non-traceable Author Statement
more info
PubMed 
glucose import in response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of brain-derived neurotrophic factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic vesicle budding from presynaptic endocytic zone membrane IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
short-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
T-tubule IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endomembrane system ISS
Inferred from Sequence or Structural Similarity
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
insulin-responsive compartment IDA
Inferred from Direct Assay
more info
PubMed 
insulin-responsive compartment ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
multivesicular body IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network transport vesicle IEA
Inferred from Electronic Annotation
more info
 
vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 4
Names
GLUT-4
glucose transporter type 4, insulin-responsive
insulin-responsive glucose transporter type 4
solute carrier family 2 (facilitated glucose transporter), member 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012127.1 RefSeqGene

    Range
    4984..11523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042.3NP_001033.1  solute carrier family 2, facilitated glucose transporter member 4

    See identical proteins and their annotated locations for NP_001033.1

    Status: REVIEWED

    Source sequence(s)
    AC003688, AL521328, BC034387, BQ775137, CF594356, M20747
    Consensus CDS
    CCDS11097.1
    UniProtKB/Swiss-Prot
    P14672
    Related
    ENSP00000320935.8, ENST00000317370.13
    Conserved Domains (1) summary
    pfam00083
    Location:27483
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7281718..7288257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p13 PATCHES

    Range
    37046..43585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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