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Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 [ Mus musculus (house mouse) ]

Gene ID: 20510, updated on 11-Apr-2024

Summary

Official Symbol
Slc1a1provided by MGI
Official Full Name
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1provided by MGI
Primary source
MGI:MGI:105083
See related
Ensembl:ENSMUSG00000024935 AllianceGenome:MGI:105083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAAC1; EAAC2; EAAT3; MEAAC1; D130048G10Rik
Summary
Enables anion transmembrane transporter activity and identical protein binding activity. Involved in several processes, including cation transmembrane transport; learning or memory; and response to alkaloid. Acts upstream of or within several processes, including behavioral fear response; ion homeostasis; and regulation of cellular protein metabolic process. Located in several cellular components, including apical plasma membrane; endosome membrane; and membrane raft. Is integral component of plasma membrane. Is active in cytoplasm and dendrite. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Used to study dicarboxylic aminoaciduria and low tension glaucoma. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 43.4), kidney adult (RPKM 33.9) and 13 other tissues See more
Orthologs
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Genomic context

Location:
19 C1; 19 23.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (28812535..28891360)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (28835135..28913960)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15A, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_45871 Neighboring gene predicted gene, 35922 Neighboring gene dynein family member Neighboring gene STARR-seq mESC enhancer starr_45873 Neighboring gene predicted gene, 52404 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene spermatogenesis associated 6 like Neighboring gene phospholipid phosphatase 6 Neighboring gene phytanoyl-CoA hydroxylase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-aspartate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-aspartate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-glutamate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-glutamate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutamate:sodium symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables high-affinity L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic anion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in D-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in D-aspartate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-aspartate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-glutamate import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within L-glutamate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of protein kinase B activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to ammonium ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to ammonium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to bisphenol A IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to mercury ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in conditioned place preference IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cysteine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cysteine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutathione biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular glutamate homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maintenance of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within motor neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurotransmitter receptor transport to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to anesthetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to anesthetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to axon injury IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to decreased oxygen levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to decreased oxygen levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to morphine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retina layer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina layer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within righting reflex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zinc ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in distal dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perisynaptic space ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in proximal dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic cleft ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
excitatory amino acid transporter 3
Names
excitatory amino acid carrier 2
excitatory amino-acid carrier 1
glutamate transporter mEAAC2
sodium-dependent glutamate/aspartate transporter 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009199.3NP_033225.1  excitatory amino acid transporter 3

    See identical proteins and their annotated locations for NP_033225.1

    Status: VALIDATED

    Source sequence(s)
    AC113961, AC163993
    Consensus CDS
    CCDS29727.1
    UniProtKB/Swiss-Prot
    O35869, O35875, P51906, Q6P1F7
    UniProtKB/TrEMBL
    Q9D393
    Related
    ENSMUSP00000025875.5, ENSMUST00000025875.5
    Conserved Domains (1) summary
    pfam00375
    Location:51464
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    28812535..28891360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)