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Slc19a1 solute carrier family 19 (folate transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 20509, updated on 8-Dec-2022

Summary

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Official Symbol
Slc19a1provided by MGI
Official Full Name
solute carrier family 19 (folate transporter), member 1provided by MGI
Primary source
MGI:MGI:103182
See related
Ensembl:ENSMUSG00000001436 AllianceGenome:MGI:103182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RFC; RFC1; RFC-1
Summary
Enables folic acid transmembrane transporter activity and methotrexate transmembrane transporter activity. Involved in folate import across plasma membrane and methotrexate transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cleft lip; dextro-looped transposition of the great arteries; hematologic cancer; and malaria. Orthologous to human SLC19A1 (solute carrier family 19 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 62.7), ovary adult (RPKM 25.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Slc19a1 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76868103..76886266)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77032269..77050432)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35721 Neighboring gene predicted gene 10787 Neighboring gene predicted gene, 3137 Neighboring gene collagen, type XVIII, alpha 1 Neighboring gene spermidine synthase pseudogene Neighboring gene predicted gene, 35837 Neighboring gene predicted gene, 40704

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of the Receptor Used by the Ecotropic Mouse GLN Endogenous Retrovirus. Tsang J, et al. J Virol, 2019 Mar 1. PMID 30541852, Free PMC Article
  2. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. Toriyama M, et al. FASEB J, 2017 Aug. PMID 28432198, Free PMC Article
  3. Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model. Hashizume M, et al. Arthritis Res Ther, 2012 Apr 30. PMID 22546471, Free PMC Article
  4. Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates. Liu M, et al. J Biol Chem, 2005 Feb 18. PMID 15579899
  5. Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart. Maddox DM, et al. BMC Dev Biol, 2003 Jul 29. PMID 12887734, Free PMC Article

See all (61) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors identified the cellular protein used as a receptor by GLN Endogenous Retrovirus for cell entry as SLC19A1, the reduced folate carrier.
    Title: Identification of the Receptor Used by the Ecotropic Mouse GLN Endogenous Retrovirus.
  2. The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cel embryos and blastocysts.
    Title: Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.
  3. Interleukin-6 regulated the efficacy of methotrexate by decreasing the expression of SLC19A1.
    Title: Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model.
  4. expressed in placenta at highest level during early development
    Title: Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.
  5. Intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC and PCFT.
    Title: Differentiation-dependent regulation of the intestinal folate uptake process: studies with Caco-2 cells and native mouse intestine.
  6. Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients.
    Title: Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.
  7. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
    Title: Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
  8. existence of four unique noncoding exons and promoters for mRFC and demonstrate a facile induction of mRNAs for mRFC and multidrug resistance-associated proteins 1 and 3 in intestine in response to changes in dietary folate intake
    Title: Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates.
  9. First evidence of RFC expression in rapidly dividing cells of developing neural tube, craniofacial region, limb buds and heart duggests that these regions may be particularly susceptible to folate deficiency.
    Title: Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart.
  10. interaction between the E45 and K404 residues in the first and 11th transmembrane domains; the E45 residue appears to be the more dominant determinant of binding and anion sensitivity
    Title: Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2',3'-cyclic GMP-AMP binding ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables cyclic-GMP-AMP transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables folate:monoatomic anion antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables folate:monoatomic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables folic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables folic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables folic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables methotrexate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methotrexate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables vitamin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in folate import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in folate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in folate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in folate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in folate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in folic acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in methotrexate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in methotrexate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
reduced folate transporter
Names
IFC-1
folate transporter 1
intestinal folate carrier 1
intestinal folate carrier protein
plasma membrane folate antiporter SLC19A1
reduced folate carrier 1
solute carrier family 19 (sodium/hydrogen exchanger), member 1
solute carrier family 19 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199271.1 → NP_001186200.1  reduced folate transporter

    See identical proteins and their annotated locations for NP_001186200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI323572, BC015263, BF786711
    Consensus CDS
    CCDS35947.1
    UniProtKB/Swiss-Prot
    P41438, Q62451
    UniProtKB/TrEMBL
    Q542F3
    Related
    ENSMUSP00000116784.2, ENSMUST00000144234.8
    Conserved Domains (1) summary
    TIGR00806
    Location:1 → 512
    rfc; RFC reduced folate carrier

  2. NM_031196.3 → NP_112473.1  reduced folate transporter

    See identical proteins and their annotated locations for NP_112473.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer and more frequently occurring transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI323572, AK079592, BY791593
    Consensus CDS
    CCDS35947.1
    UniProtKB/Swiss-Prot
    P41438, Q62451
    UniProtKB/TrEMBL
    Q542F3
    Related
    ENSMUSP00000101050.4, ENSMUST00000105410.10
    Conserved Domains (1) summary
    TIGR00806
    Location:1 → 512
    rfc; RFC reduced folate carrier

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    76868103..76886266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513416.4 → XP_006513479.1  reduced folate transporter isoform X1

    See identical proteins and their annotated locations for XP_006513479.1

    UniProtKB/Swiss-Prot
    P41438, Q62451
    UniProtKB/TrEMBL
    Q542F3
    Conserved Domains (1) summary
    TIGR00806
    Location:1 → 512
    rfc; RFC reduced folate carrier

  2. XM_006513417.4 → XP_006513480.1  reduced folate transporter isoform X1

    See identical proteins and their annotated locations for XP_006513480.1

    UniProtKB/Swiss-Prot
    P41438, Q62451
    UniProtKB/TrEMBL
    Q542F3
    Conserved Domains (1) summary
    TIGR00806
    Location:1 → 512
    rfc; RFC reduced folate carrier

  3. XM_030244971.2 → XP_030100831.1  reduced folate transporter isoform X2

    Conserved Domains (1) summary
    cl27502
    Location:1 → 273
    Folate_carrier; Reduced folate carrier

  4. XM_006513414.5 → XP_006513477.1  reduced folate transporter isoform X1

    See identical proteins and their annotated locations for XP_006513477.1

    UniProtKB/Swiss-Prot
    P41438, Q62451
    UniProtKB/TrEMBL
    Q542F3
    Conserved Domains (1) summary
    TIGR00806
    Location:1 → 512
    rfc; RFC reduced folate carrier

  5. XM_006513419.5 → XP_006513482.1  reduced folate transporter isoform X2

    Conserved Domains (1) summary
    cl27502
    Location:1 → 273
    Folate_carrier; Reduced folate carrier

  6. XM_036155714.1 → XP_036011607.1  reduced folate transporter isoform X3

    Conserved Domains (1) summary
    cl27502
    Location:1 → 273
    Folate_carrier; Reduced folate carrier

  7. XM_006513415.5 → XP_006513478.1  reduced folate transporter isoform X1

    See identical proteins and their annotated locations for XP_006513478.1

    UniProtKB/Swiss-Prot
    P41438, Q62451
    UniProtKB/TrEMBL
    Q542F3
    Conserved Domains (1) summary
    TIGR00806
    Location:1 → 512
    rfc; RFC reduced folate carrier

  8. XM_036155713.1 → XP_036011606.1  reduced folate transporter isoform X1

    UniProtKB/Swiss-Prot
    Q62451
    UniProtKB/TrEMBL
    Q542F3
    Conserved Domains (1) summary
    TIGR00806
    Location:1 → 512
    rfc; RFC reduced folate carrier

RNA

  1. XR_003948633.2 RNA Sequence

  2. XR_004936130.1 RNA Sequence

  3. XR_004936132.1 RNA Sequence

  4. XR_003948634.2 RNA Sequence

  5. XR_004936133.1 RNA Sequence

  6. XR_004936131.1 RNA Sequence

  7. XR_003948632.2 RNA Sequence

  8. XR_003948631.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41438.1 GenPept UniProtKB/Swiss-Prot:P41438

Gene LinkOut

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