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Sipa1 signal-induced proliferation associated gene 1 [ Mus musculus (house mouse) ]

Gene ID: 20469, updated on 18-Apr-2024

Summary

Official Symbol
Sipa1provided by MGI
Official Full Name
signal-induced proliferation associated gene 1provided by MGI
Primary source
MGI:MGI:107576
See related
Ensembl:ENSMUSG00000056917 AllianceGenome:MGI:107576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spa1
Summary
Predicted to enable GTPase activator activity and protein C-terminus binding activity. Acts upstream of or within regulation of cell cycle. Predicted to be located in transport vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; heart; immune system; liver; and lung. Used to study chronic myeloid leukemia. Orthologous to human SIPA1 (signal-induced proliferation-associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 156.5), thymus adult (RPKM 70.0) and 18 other tissues See more
Orthologs
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Genomic context

Location:
19 A; 19 4.34 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5701211..5713758, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5651185..5663722, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11011 Neighboring gene K(lysine) acetyltransferase 5 Neighboring gene v-rel reticuloendotheliosis viral oncogene homolog A (avian) Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene STARR-positive B cell enhancer ABC_E4259 Neighboring gene STARR-positive B cell enhancer ABC_E11012 Neighboring gene mitogen-activated protein kinase kinase kinase 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4074

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to water deprivation ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of epithelial cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal-induced proliferation-associated protein 1
Names
GTPase-activating protein Spa-1
sipa-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164480.2NP_001157952.1  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_001157952.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000128208.2, ENSMUST00000164304.9
    Conserved Domains (4) summary
    PHA03378
    Location:29112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:9011023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347528
    Rap_GAP; Rap/ran-GAP
  2. NM_001164481.2NP_001157953.1  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_001157953.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000073618.6, ENSMUST00000071857.13
    Conserved Domains (4) summary
    PHA03378
    Location:29112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:9011023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347528
    Rap_GAP; Rap/ran-GAP
  3. NM_001164482.2NP_001157954.1  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_001157954.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000157692.2, ENSMUST00000237874.2
    Conserved Domains (4) summary
    PHA03378
    Location:29112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:9011023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347528
    Rap_GAP; Rap/ran-GAP
  4. NM_001164568.2NP_001158040.1  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_001158040.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000132345.2, ENSMUST00000169854.2
    Conserved Domains (4) summary
    PHA03378
    Location:29112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:9011023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347528
    Rap_GAP; Rap/ran-GAP
  5. NM_001403064.1NP_001389993.1  signal-induced proliferation-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    UniProtKB/TrEMBL
    E9Q0Y4
  6. NM_001403065.1NP_001389994.1  signal-induced proliferation-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    UniProtKB/TrEMBL
    E9Q0Y4
  7. NM_011379.5NP_035509.4  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_035509.4

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000079637.6, ENSMUST00000080824.13
    Conserved Domains (4) summary
    PHA03378
    Location:29112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:9011023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347528
    Rap_GAP; Rap/ran-GAP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5701211..5713758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161493.1XP_036017386.1  signal-induced proliferation-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Conserved Domains (4) summary
    PHA03378
    Location:29112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:9011023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347528
    Rap_GAP; Rap/ran-GAP