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SIPA1 signal-induced proliferation-associated 1 [ Homo sapiens (human) ]

Gene ID: 6494, updated on 13-Mar-2020

Summary

Official Symbol
SIPA1provided by HGNC
Official Full Name
signal-induced proliferation-associated 1provided by HGNC
Primary source
HGNC:HGNC:10885
See related
Ensembl:ENSG00000213445 MIM:602180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPA1
Summary
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 30.1), lymph node (RPKM 17.9) and 24 other tissues See more
Orthologs

Genomic context

See SIPA1 in Genome Data Viewer
Location:
11q13.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65638101..65650930)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65405578..65418391)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene pecanex 3 Neighboring gene microRNA 4690 Neighboring gene microRNA 4489 Neighboring gene RELA proto-oncogene, NF-kB subunit Neighboring gene RELA divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17037, MGC102688

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to water deprivation IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
signal-induced proliferation-associated protein 1
Names
GTPase-activating protein Spa-1
p130 SPA-1
signal-induced proliferation-associated gene 1
sipa-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006747.4NP_006738.3  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_006738.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AP001362
    Consensus CDS
    CCDS8108.1
    UniProtKB/Swiss-Prot
    Q96FS4
    Related
    ENSP00000436269.1, ENST00000534313.6
    Conserved Domains (4) summary
    pfam00595
    Location:687759
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:351532
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:9741030
    ZapB; Cell division protein ZapB
    cl25732
    Location:9051027
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_153253.29NP_694985.29  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_694985.29

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB005666, AI307277, BC010492
    Consensus CDS
    CCDS8108.1
    UniProtKB/Swiss-Prot
    Q96FS4
    Related
    ENSP00000377771.3, ENST00000394224.3
    Conserved Domains (4) summary
    pfam00595
    Location:687759
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:351532
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:9741030
    ZapB; Cell division protein ZapB
    cl25732
    Location:9051027
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65638101..65650930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274189.2XP_005274246.1  signal-induced proliferation-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005274246.1

    UniProtKB/Swiss-Prot
    Q96FS4
    Related
    ENSP00000433686.1, ENST00000527525.5
    Conserved Domains (4) summary
    pfam00595
    Location:687759
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:351532
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:9741030
    ZapB; Cell division protein ZapB
    cl25732
    Location:9051027
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_247210.2 RNA Sequence

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