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INTS6L integrator complex subunit 6 like [ Homo sapiens (human) ]

Gene ID: 203522, updated on 15-Sep-2022

Summary

Official Symbol
INTS6Lprovided by HGNC
Official Full Name
integrator complex subunit 6 likeprovided by HGNC
Primary source
HGNC:HGNC:27334
See related
Ensembl:ENSG00000165359 AllianceGenome:HGNC:27334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX26B
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 6.8), bone marrow (RPKM 4.6) and 23 other tissues See more
Orthologs
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Genomic context

See INTS6L in Genome Data Viewer
Location:
Xq26.3
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135520660..135582510)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (133846416..133908261)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134654585..134716435)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CROCC pseudogene 1 Neighboring gene WDR4 pseudogene 1 Neighboring gene INTS6L antisense RNA 1 Neighboring gene ETS2 pseudogene 1 Neighboring gene sarcoma antigen 4, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41215, MGC88298, DKFZp686G0470

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
integrator complex subunit 6-like
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
protein DDX26B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055290.2 RefSeqGene

    Range
    5002..66852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351601.3NP_001338530.1  integrator complex subunit 6-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Consensus CDS
    CCDS87784.1
    UniProtKB/TrEMBL
    A0A1W2PPI5
    Related
    ENSP00000491427.1, ENST00000639893.2
    Conserved Domains (2) summary
    pfam13519
    Location:4132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:814875
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  2. NM_001351603.3NP_001338532.1  integrator complex subunit 6-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Conserved Domains (2) summary
    pfam13519
    Location:4132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:777838
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  3. NM_001351604.3NP_001338533.1  integrator complex subunit 6-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Conserved Domains (2) summary
    pfam13519
    Location:4132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:733794
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  4. NM_001351605.3NP_001338534.1  integrator complex subunit 6-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Conserved Domains (2) summary
    pfam13519
    Location:4132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:733794
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  5. NM_001351606.3NP_001338535.1  integrator complex subunit 6-like isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Conserved Domains (1) summary
    pfam15300
    Location:535596
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  6. NM_182540.7NP_872346.3  integrator complex subunit 6-like isoform 1

    See identical proteins and their annotated locations for NP_872346.3

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Consensus CDS
    CCDS35401.1
    UniProtKB/Swiss-Prot
    Q5JSJ4, Q6ZWE4
    Related
    ENSP00000359788.4, ENST00000370752.4
    Conserved Domains (2) summary
    cd00198
    Location:4131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:777838
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RNA

  1. NR_147256.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Related
    ENST00000481908.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    135520660..135582510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724740.3XP_006724803.1  integrator complex subunit 6-like isoform X1

    Conserved Domains (2) summary
    cd00198
    Location:4131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:814875
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  2. XM_006724741.5XP_006724804.1  integrator complex subunit 6-like isoform X2

    Conserved Domains (2) summary
    cd00198
    Location:4131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:770831
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  3. XM_024452350.2XP_024308118.1  integrator complex subunit 6-like isoform X3

    Conserved Domains (2) summary
    pfam13519
    Location:4132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:770831
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  4. XM_047441910.1XP_047297866.1  integrator complex subunit 6-like isoform X10

  5. XM_017029346.2XP_016884835.1  integrator complex subunit 6-like isoform X12

  6. XM_011531311.3XP_011529613.1  integrator complex subunit 6-like isoform X13

    Conserved Domains (1) summary
    cd00198
    Location:4131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  7. XM_047441913.1XP_047297869.1  integrator complex subunit 6-like isoform X15

    UniProtKB/TrEMBL
    Q8N8M2
  8. XM_047441912.1XP_047297868.1  integrator complex subunit 6-like isoform X14

  9. XM_017029349.2XP_016884838.1  integrator complex subunit 6-like isoform X16

    Conserved Domains (1) summary
    cd00198
    Location:4100
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  10. XM_047441909.1XP_047297865.1  integrator complex subunit 6-like isoform X9

  11. XM_047441907.1XP_047297863.1  integrator complex subunit 6-like isoform X7

  12. XM_047441905.1XP_047297861.1  integrator complex subunit 6-like isoform X5

  13. XM_047441908.1XP_047297864.1  integrator complex subunit 6-like isoform X8

  14. XM_047441904.1XP_047297860.1  integrator complex subunit 6-like isoform X4

  15. XM_047441906.1XP_047297862.1  integrator complex subunit 6-like isoform X6

  16. XM_047441911.1XP_047297867.1  integrator complex subunit 6-like isoform X11

RNA

  1. XR_007068183.1 RNA Sequence

  2. XR_001755668.2 RNA Sequence

  3. XR_001755666.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    133846416..133908261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)