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INTS6L integrator complex subunit 6 like [ Homo sapiens (human) ]

Gene ID: 203522, updated on 12-Oct-2019

Summary

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Official Symbol
INTS6Lprovided by HGNC
Official Full Name
integrator complex subunit 6 likeprovided by HGNC
Primary source
HGNC:HGNC:27334
See related
Ensembl:ENSG00000165359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX26B
Expression
Ubiquitous expression in lymph node (RPKM 6.8), bone marrow (RPKM 4.6) and 23 other tissues See more
Orthologs
all

Genomic context

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See INTS6L in Genome Data Viewer
Location:
Xq26.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (135520630..135582537)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134654555..134716460)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CROCC pseudogene 1 Neighboring gene WD repeat domain 4 pseudogene Neighboring gene INTS6L antisense RNA 1 Neighboring gene ETS proto-oncogene 2, transcription factor Neighboring gene sarcoma antigen 4, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Malovannaya A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133760, Free PMC Article
  2. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

See all (11) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41215, MGC88298, DKFZp686G0470

Gene Ontology Provided by GOA

Process Evidence Code Pubs
snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
integrator complex subunit 6-like
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
protein DDX26B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055290.1 RefSeqGene

    Range
    5001..66910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351601.2 → NP_001338530.1  integrator complex subunit 6-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Consensus CDS
    CCDS87784.1
    Related
    ENSP00000491427.1, ENST00000639893.1
    Conserved Domains (2) summary
    pfam13519
    Location:4 → 132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:814 → 875
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  2. NM_001351603.2 → NP_001338532.1  integrator complex subunit 6-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Conserved Domains (2) summary
    pfam13519
    Location:4 → 132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:777 → 838
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  3. NM_001351604.2 → NP_001338533.1  integrator complex subunit 6-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Conserved Domains (2) summary
    pfam13519
    Location:4 → 132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:733 → 794
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  4. NM_001351605.2 → NP_001338534.1  integrator complex subunit 6-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Conserved Domains (2) summary
    pfam13519
    Location:4 → 132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:733 → 794
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  5. NM_001351606.2 → NP_001338535.1  integrator complex subunit 6-like isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Conserved Domains (1) summary
    pfam15300
    Location:535 → 596
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  6. NM_182540.6 → NP_872346.3  integrator complex subunit 6-like isoform 1

    See identical proteins and their annotated locations for NP_872346.3

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Consensus CDS
    CCDS35401.1
    UniProtKB/Swiss-Prot
    Q5JSJ4
    Related
    ENSP00000359788.4, ENST00000370752.4
    Conserved Domains (2) summary
    cd00198
    Location:4 → 131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:777 → 838
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RNA

  1. NR_147256.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL357834, AL391380
    Related
    ENST00000481908.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    135520630..135582537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724740.2 → XP_006724803.1  integrator complex subunit 6-like isoform X1

    Conserved Domains (2) summary
    cd00198
    Location:4 → 131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:814 → 875
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  2. XM_024452350.1 → XP_024308118.1  integrator complex subunit 6-like isoform X3

    Conserved Domains (2) summary
    pfam13519
    Location:4 → 132
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:770 → 831
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  3. XM_017029346.1 → XP_016884835.1  integrator complex subunit 6-like isoform X4

  4. XM_011531311.2 → XP_011529613.1  integrator complex subunit 6-like isoform X5

    Conserved Domains (1) summary
    cd00198
    Location:4 → 131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  5. XM_017029347.1 → XP_016884836.1  integrator complex subunit 6-like isoform X6

  6. XM_017029349.1 → XP_016884838.1  integrator complex subunit 6-like isoform X7

    Conserved Domains (1) summary
    cd00198
    Location:4 → 100
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  7. XM_006724741.4 → XP_006724804.1  integrator complex subunit 6-like isoform X2

    Conserved Domains (2) summary
    cd00198
    Location:4 → 131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:770 → 831
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RNA

  1. XR_430544.2 RNA Sequence

  2. XR_001755665.1 RNA Sequence

  3. XR_002958766.1 RNA Sequence

    Related
    ENST00000493637.6

  4. XR_001755670.1 RNA Sequence

  5. XR_001755671.1 RNA Sequence

  6. XR_001755668.1 RNA Sequence

  7. XR_001755669.1 RNA Sequence

  8. XR_001755666.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JSJ4.1 GenPept UniProtKB/Swiss-Prot:Q5JSJ4

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