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Scn1b sodium channel, voltage-gated, type I, beta [ Mus musculus (house mouse) ]

Gene ID: 20266, updated on 5-Mar-2024

Summary

Official Symbol
Scn1bprovided by MGI
Official Full Name
sodium channel, voltage-gated, type I, betaprovided by MGI
Primary source
MGI:MGI:98247
See related
Ensembl:ENSMUSG00000019194 AllianceGenome:MGI:98247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables sodium channel inhibitor activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in several processes, including membrane depolarization during cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; and sodium ion transmembrane transport. Acts upstream of or within corticospinal neuron axon guidance; neuronal action potential propagation; and positive regulation of neuron projection development. Located in T-tubule; intercalated disc; and node of Ranvier. Part of sodium channel complex. Is expressed in heart. Used to study generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 317.2), cortex adult (RPKM 267.6) and 9 other tissues See more
Orthologs
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Genomic context

See Scn1b in Genome Data Viewer
Location:
7 B1; 7 19.3 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30815949..30826436, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (31116524..31127023, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene predicted gene, 53358 Neighboring gene STARR-positive B cell enhancer mm9_chr7:31896031-31896332 Neighboring gene hepsin Neighboring gene GRAM domain containing 1A Neighboring gene STARR-seq mESC enhancer starr_18545 Neighboring gene STARR-seq mESC enhancer starr_18546 Neighboring gene predicted gene 10640

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell action potential involved in contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cardiac muscle cell action potential involved in contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within corticospinal neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during Purkinje myocyte cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuronal action potential propagation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to pyrethroid ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in node of Ranvier IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with node of Ranvier ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of sodium channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated sodium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium channel subunit beta-1
Names
sodium channel, voltage-gated, type I, beta polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402334.1NP_001389263.1  sodium channel subunit beta-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158993
    Conserved Domains (2) summary
    cd00096
    Location:2225
    Ig; Ig strand C [structural motif]
    pfam07686
    Location:8114
    V-set; Immunoglobulin V-set domain
  2. NM_011322.4NP_035452.1  sodium channel subunit beta-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035452.1

    Status: VALIDATED

    Source sequence(s)
    AC158993
    Consensus CDS
    CCDS21126.1
    UniProtKB/Swiss-Prot
    P97952
    Related
    ENSMUSP00000096148.5, ENSMUST00000098548.8
    Conserved Domains (1) summary
    pfam07686
    Location:23147
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30815949..30826436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)