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Sars seryl-aminoacyl-tRNA synthetase [ Mus musculus (house mouse) ]

Gene ID: 20226, updated on 5-Jan-2023

Summary

Official Symbol
Sarsprovided by MGI
Official Full Name
seryl-aminoacyl-tRNA synthetaseprovided by MGI
Primary source
MGI:MGI:102809
See related
Ensembl:ENSMUSG00000068739 AllianceGenome:MGI:102809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Strs; Sars1; serRS
Summary
Predicted to enable several functions, including nucleic acid binding activity; protein homodimerization activity; and serine-tRNA ligase activity. Predicted to be involved in negative regulation of angiogenesis; negative regulation of macromolecule metabolic process; and seryl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 31.6), CNS E11.5 (RPKM 30.2) and 28 other tissues See more
Orthologs
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Genomic context

See Sars in Genome Data Viewer
Location:
3 F3; 3 47.08 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108332180..108352575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108424864..108445259, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene proline/serine-rich coiled-coil 1 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene predicted gene, 52630 Neighboring gene predicted gene, 22942 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator 1 Neighboring gene predicted gene, 23336 Neighboring gene cilia and flagella associated protein 276

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables selenocysteine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in selenocysteine incorporation ISO
Inferred from Sequence Orthology
more info
 
involved_in seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in seryl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine--tRNA ligase, cytoplasmic
Names
seryl-aminoacyl-tRNA synthetase 1
seryl-tRNA synthetase, cytoplasmic
seryl-tRNA(Ser/Sec) synthetase
NP_001191908.1
NP_035449.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204979.1NP_001191908.1  serine--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001191908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK028358, AK075827, BP765728, BY034232
    Consensus CDS
    CCDS57254.1
    UniProtKB/Swiss-Prot
    A2AFR8, P26638
    Related
    ENSMUSP00000088041.6, ENSMUST00000090553.12
    Conserved Domains (3) summary
    PLN02678
    Location:3486
    PLN02678; seryl-tRNA synthetase
    cd00770
    Location:152460
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    pfam02403
    Location:3109
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  2. NM_011319.3NP_035449.1  serine--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_035449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK028358, AK082793, BP765728, BY034232
    Consensus CDS
    CCDS17760.1
    UniProtKB/TrEMBL
    Q8C483
    Related
    ENSMUSP00000099685.5, ENSMUST00000102625.11
    Conserved Domains (3) summary
    PLN02678
    Location:3510
    PLN02678; seryl-tRNA synthetase
    cd00770
    Location:152484
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    pfam02403
    Location:3109
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108332180..108352575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)