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SARS1 seryl-tRNA synthetase 1 [ Homo sapiens (human) ]

Gene ID: 6301, updated on 1-Jun-2020

Summary

Official Symbol
SARS1provided by HGNC
Official Full Name
seryl-tRNA synthetase 1provided by HGNC
Primary source
HGNC:HGNC:10537
See related
Ensembl:ENSG00000031698 MIM:607529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SARS; SERS; SERRS; NEDMAS
Summary
This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in thyroid (RPKM 44.0), brain (RPKM 25.3) and 25 other tissues See more
Orthologs

Genomic context

See SARS1 in Genome Data Viewer
Location:
1p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (109213893..109238182)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109756515..109780804)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 194 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator 1 Neighboring gene VISTA enhancer hs2216 Neighboring gene cadherin EGF LAG seven-pass G-type receptor 2 Neighboring gene VISTA enhancer hs2263

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with seryl-tRNA synthetase (SARS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
selenocysteine metabolic process TAS
Traceable Author Statement
more info
 
selenocysteinyl-tRNA(Sec) biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
seryl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
seryl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
tRNA processing TAS
Traceable Author Statement
more info
PubMed 
translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine--tRNA ligase, cytoplasmic
Names
serine tRNA ligase 1, cytoplasmic
seryl-tRNA synthetase, cytoplasmic
seryl-tRNA(Ser/Sec) synthetase
NP_001317598.1
NP_006504.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330669.1NP_001317598.1  serine--tRNA ligase, cytoplasmic isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (b).
    Source sequence(s)
    AL356389
    Consensus CDS
    CCDS81356.1
    UniProtKB/TrEMBL
    Q5T5C7
    Related
    ENSP00000358939.4, ENST00000369923.4
  2. NM_006513.4NP_006504.2  serine--tRNA ligase, cytoplasmic isoform a

    See identical proteins and their annotated locations for NP_006504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform b.
    Source sequence(s)
    BC009390, BC111398, BM666450
    Consensus CDS
    CCDS795.1
    UniProtKB/Swiss-Prot
    P49591
    UniProtKB/TrEMBL
    Q0VGA5
    Related
    ENSP00000234677.2, ENST00000234677.7
    Conserved Domains (1) summary
    cl28419
    Location:3486
    SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_034072.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon for its 3' end and lacks a large portion of the coding region, compared to variant 1. This variant is represented as non-coding because the transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because uncertainty exists about the protein-coding capacity of the transcript.
    Source sequence(s)
    AL356389, BM798814, BP363347, DA792457

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    109213893..109238182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_034073.1: Suppressed sequence

    Description
    NR_034073.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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