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Sag S-antigen, retina and pineal gland (arrestin) [ Mus musculus (house mouse) ]

Gene ID: 20215, updated on 5-Mar-2024

Summary

Official Symbol
Sagprovided by MGI
Official Full Name
S-antigen, retina and pineal gland (arrestin)provided by MGI
Primary source
MGI:MGI:98227
See related
Ensembl:ENSMUSG00000056055 AllianceGenome:MGI:98227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arr1; Irbp; arrestin; A930001K18Rik
Summary
Enables opsin binding activity and phosphoprotein binding activity. Predicted to be involved in G protein-coupled receptor internalization. Located in photoreceptor inner segment and photoreceptor outer segment. Is expressed in eye and retina outer nuclear layer. Human ortholog(s) of this gene implicated in Oguchi disease-1; hereditary night blindness; and retinitis pigmentosa 47. Orthologous to human SAG (S-antigen visual arrestin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.9), genital fat pad adult (RPKM 0.3) and 7 other tissues See more
Orthologs
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Genomic context

Location:
1 D; 1 44.44 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87731402..87772880)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87798143..87845158)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 16 like 1 Neighboring gene predicted gene, 25395 Neighboring gene predicted gene, 53572 Neighboring gene small Cajal body-specific RNA 6 Neighboring gene STARR-seq mESC enhancer starr_01624 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:89724892-89725168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:89743594-89743830 Neighboring gene STARR-positive B cell enhancer ABC_E10019 Neighboring gene STARR-positive B cell enhancer mm9_chr1:89763253-89763553 Neighboring gene predicted gene, 19582 Neighboring gene STARR-seq mESC enhancer starr_01625 Neighboring gene diacylglycerol kinase, delta Neighboring gene ubiquitin specific peptidase 40

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables opsin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in photoreceptor inner segment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
S-arrestin
Names
48 kDa protein
S-AG
arrestin 1
retinal S-antigen
rod arrestin
rod photoreceptor arrestin
visual arrestin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009118.2NP_033144.1  S-arrestin

    See identical proteins and their annotated locations for NP_033144.1

    Status: VALIDATED

    Source sequence(s)
    AC102630, M24086
    Consensus CDS
    CCDS35656.1
    UniProtKB/Swiss-Prot
    P20443, Q91W62
    UniProtKB/TrEMBL
    Q3UEW3, Q3UPX6
    Related
    ENSMUSP00000076948.6, ENSMUST00000077772.12
    Conserved Domains (2) summary
    smart01017
    Location:200361
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:23181
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87731402..87772880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252327.2XP_030108187.1  S-arrestin isoform X1

    UniProtKB/Swiss-Prot
    P20443, Q91W62
    UniProtKB/TrEMBL
    Q3UEW3, Q3UPX6
    Conserved Domains (2) summary
    smart01017
    Location:200361
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:23181
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. XM_011247944.4XP_011246246.1  S-arrestin isoform X4

    UniProtKB/TrEMBL
    Q3UEW3
    Conserved Domains (2) summary
    smart01017
    Location:125286
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:1106
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  3. XM_006529274.2XP_006529337.1  S-arrestin isoform X2

    UniProtKB/TrEMBL
    Q3UEW3
    Conserved Domains (2) summary
    smart01017
    Location:145306
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:2126
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. XM_036162886.1XP_036018779.1  S-arrestin isoform X3

    UniProtKB/TrEMBL
    Q3UEW3
    Conserved Domains (2) summary
    smart01017
    Location:145298
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:2126
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  5. XM_030252329.1XP_030108189.1  S-arrestin isoform X5

    UniProtKB/TrEMBL
    Q8C8Y8
    Conserved Domains (2) summary
    smart01017
    Location:145298
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:2126
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  6. XM_036162893.1XP_036018786.1  S-arrestin isoform X6

    Conserved Domains (1) summary
    smart01017
    Location:16177
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain