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S100a4 S100 calcium binding protein A4 [ Mus musculus (house mouse) ]

Gene ID: 20198, updated on 16-Oct-2021

Summary

Official Symbol
S100a4provided by MGI
Official Full Name
S100 calcium binding protein A4provided by MGI
Primary source
MGI:MGI:1330282
See related
Ensembl:ENSMUSG00000001020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
42a; 18A2; Capl; FSp1; Mts1; pk9a; PeL98; metastasin
Expression
Biased expression in bladder adult (RPKM 53.9), mammary gland adult (RPKM 13.8) and 10 other tissues See more
Orthologs
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Genomic context

See S100a4 in Genome Data Viewer
Location:
3 F1; 3 39.27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90511077..90513352)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90603770..90606045)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (90407692..90409967)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A3 Neighboring gene predicted gene, 54169 Neighboring gene S100 calcium binding protein A2 Neighboring gene S100 calcium binding protein A5 Neighboring gene S100 calcium binding protein A6 (calcyclin)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RAGE receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RAGE receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein S100-A4
Names
Fibroblast-specific protein 1
calvasculin
metastatic cell protein
placental calcium-binding protein
protein 18A2
protein Mts1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011311.2NP_035441.1  protein S100-A4

    See identical proteins and their annotated locations for NP_035441.1

    Status: VALIDATED

    Source sequence(s)
    AK160522, BX526220
    Consensus CDS
    CCDS17538.1
    UniProtKB/Swiss-Prot
    P07091
    UniProtKB/TrEMBL
    Q545V2
    Related
    ENSMUSP00000001046.6, ENSMUST00000001046.7
    Conserved Domains (1) summary
    cd00213
    Location:490
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90511077..90513352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501178.3XP_006501241.1  protein S100-A4 isoform X1

    See identical proteins and their annotated locations for XP_006501241.1

    UniProtKB/Swiss-Prot
    P07091
    UniProtKB/TrEMBL
    Q545V2
    Conserved Domains (1) summary
    cd00213
    Location:490
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
  2. XM_006501177.4XP_006501240.1  protein S100-A4 isoform X1

    See identical proteins and their annotated locations for XP_006501240.1

    UniProtKB/Swiss-Prot
    P07091
    UniProtKB/TrEMBL
    Q545V2
    Conserved Domains (1) summary
    cd00213
    Location:490
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
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