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S100A4 S100 calcium binding protein A4 [ Homo sapiens (human) ]

Gene ID: 6275, updated on 9-Dec-2018

Summary

Official Symbol
S100A4provided by HGNC
Official Full Name
S100 calcium binding protein A4provided by HGNC
Primary source
HGNC:HGNC:10494
See related
Ensembl:ENSG00000196154 MIM:114210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 268.4), bone marrow (RPKM 235.9) and 21 other tissues See more
Orthologs

Genomic context

See S100A4 in Genome Data Viewer
Location:
1q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (153543619..153545806, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153516095..153518282, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A6 Neighboring gene S100 calcium binding protein A5 Neighboring gene uncharacterized LOC101928034 Neighboring gene S100 calcium binding protein A3 Neighboring gene S100 calcium binding protein A2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: S100A3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RAGE receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA binding HDA PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
epithelial to mesenchymal transition TAS
Traceable Author Statement
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein S100-A4
Names
S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
calcium placental protein
fibroblast-specific protein-1
leukemia multidrug resistance associated protein
malignant transformation suppression 1
metastasin 1
murine placental homolog
placental calcium-binding protein
protein Mts1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027993.1 RefSeqGene

    Range
    5001..7188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002961.3NP_002952.1  protein S100-A4

    See identical proteins and their annotated locations for NP_002952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BX470102
    Consensus CDS
    CCDS1042.1
    UniProtKB/Swiss-Prot
    P26447
    Related
    ENSP00000357705.4, ENST00000368716.8
    Conserved Domains (1) summary
    cd00213
    Location:490
    S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
  2. NM_019554.2NP_062427.1  protein S100-A4

    See identical proteins and their annotated locations for NP_062427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AV735911, BC000838, BC016300, CB109749
    Consensus CDS
    CCDS1042.1
    UniProtKB/Swiss-Prot
    P26447
    Related
    ENSP00000346294.4, ENST00000354332.8
    Conserved Domains (1) summary
    cd00213
    Location:490
    S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    153543619..153545806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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