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S100A4 S100 calcium binding protein A4 [ Homo sapiens (human) ]

Gene ID: 6275, updated on 11-Jun-2025
Official Symbol
S100A4provided by HGNC
Official Full Name
S100 calcium binding protein A4provided by HGNC
Primary source
HGNC:HGNC:10494
See related
Ensembl:ENSG00000196154 MIM:114210; AllianceGenome:HGNC:10494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 268.4), bone marrow (RPKM 235.9) and 21 other tissues See more
Orthologs
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See S100A4 in Genome Data Viewer
Location:
1q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153543621..153545806, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152680877..152683062, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153516097..153518282, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 44, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1744 Neighboring gene CRISPRi-validated cis-regulatory element chr1.8692 Neighboring gene uncharacterized LOC124904423 Neighboring gene Sharpr-MPRA regulatory region 2166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153508457-153509092 Neighboring gene S100 calcium binding protein A6 Neighboring gene S100 calcium binding protein A5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153517191-153517771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153517772-153518352 Neighboring gene uncharacterized LOC101928034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153521261-153521822 Neighboring gene Sharpr-MPRA regulatory region 14368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153522386-153522947 Neighboring gene S100 calcium binding protein A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153536677-153537434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153537435-153538192 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:153538345-153539544 Neighboring gene S100 calcium binding protein A2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: S100A3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RAGE receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RAGE receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding HDA PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular matrix HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein S100-A4
Names
S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
calcium placental protein
fibroblast-specific protein-1
leukemia multidrug resistance associated protein
malignant transformation suppression 1
metastasin 1
murine placental homolog
placental calcium-binding protein
protein Mts1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027993.1 RefSeqGene

    Range
    5001..7186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002961.3NP_002952.1  protein S100-A4

    See identical proteins and their annotated locations for NP_002952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BX470102
    Consensus CDS
    CCDS1042.1
    UniProtKB/Swiss-Prot
    A8K7R8, D3DV46, P26447, Q6ICP8
    UniProtKB/TrEMBL
    Q5Q9Z3
    Related
    ENSP00000357705.4, ENST00000368716.9
    Conserved Domains (1) summary
    cd00213
    Location:490
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
  2. NM_019554.3NP_062427.1  protein S100-A4

    See identical proteins and their annotated locations for NP_062427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AV735911, BC000838, BC016300, CB109749
    Consensus CDS
    CCDS1042.1
    UniProtKB/Swiss-Prot
    A8K7R8, D3DV46, P26447, Q6ICP8
    UniProtKB/TrEMBL
    Q5Q9Z3
    Related
    ENSP00000346294.4, ENST00000354332.8
    Conserved Domains (1) summary
    cd00213
    Location:490
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153543621..153545806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152680877..152683062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)