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C4orf46 chromosome 4 open reading frame 46 [ Homo sapiens (human) ]

Gene ID: 201725, updated on 1-Oct-2021

Summary

Official Symbol
C4orf46provided by HGNC
Official Full Name
chromosome 4 open reading frame 46provided by HGNC
Primary source
HGNC:HGNC:27320
See related
Ensembl:ENSG00000205208 MIM:616210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCDG1
Summary
This gene encodes a small, conserved protein of unknown function that is expressed in a variety of tissues. There are pseudogenes for this gene on chromosomes 6, 8, 16, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Expression
Broad expression in testis (RPKM 8.9), bone marrow (RPKM 5.4) and 22 other tissues See more
Orthologs
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Genomic context

See C4orf46 in Genome Data Viewer
Location:
4q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (158666675..158672056, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159587827..159593208, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1 pseudogene Neighboring gene relaxin family peptide receptor 1 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene peptidylprolyl isomerase D Neighboring gene folliculin interacting protein 2 Neighboring gene RNA, U6 small nuclear 128, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18760

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
renal cancer differentiation gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033150.1 RefSeqGene

    Range
    5369..10581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008393.4NP_001008394.1  renal cancer differentiation gene 1 protein

    See identical proteins and their annotated locations for NP_001008394.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the protein.
    Source sequence(s)
    AC107219, BC094775, BU688970
    Consensus CDS
    CCDS34088.1
    UniProtKB/Swiss-Prot
    Q504U0
    Related
    ENSP00000368503.4, ENST00000379205.5
    Conserved Domains (1) summary
    pfam15725
    Location:587
    RCDG1; Renal cancer differentiation gene 1 protein

RNA

  1. NR_077234.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC107219, AK311718, BU688970
  2. NR_077235.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' exon and uses an alternate splice site in the 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC107219, BI823282, BU688970

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    158666675..158672056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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