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Rrm2 ribonucleotide reductase M2 [ Mus musculus (house mouse) ]

Gene ID: 20135, updated on 30-Apr-2024

Summary

Official Symbol
Rrm2provided by MGI
Official Full Name
ribonucleotide reductase M2provided by MGI
Primary source
MGI:MGI:98181
See related
Ensembl:ENSMUSG00000020649 AllianceGenome:MGI:98181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R2
Summary
Enables ferric iron binding activity and protein homodimerization activity. Contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process and protein heterotetramerization. Acts upstream of or within deoxyribonucleotide metabolic process. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 95.4), liver E14.5 (RPKM 82.1) and 10 other tissues See more
Orthologs
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Genomic context

See Rrm2 in Genome Data Viewer
Location:
12 A1.3; 12 8.5 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (24758253..24764145)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (24708254..24714146)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cystin 1 Neighboring gene predicted gene, 36129 Neighboring gene STARR-seq mESC enhancer starr_31755 Neighboring gene predicted gene, 52012 Neighboring gene STARR-positive B cell enhancer ABC_E11775 Neighboring gene predicted gene, 46316 Neighboring gene STARR-seq mESC enhancer starr_31758 Neighboring gene ribosomal protein L23A, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC113712

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoside-diphosphate reductase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoside-diphosphate reductase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of ribonucleoside-diphosphate reductase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribonucleoside-diphosphate reductase subunit M2
Names
ribonucleoside-diphosphate reductase M2 chain
ribonucleotide reductase small chain
ribonucleotide reductase small subunit
NP_033130.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009104.2NP_033130.1  ribonucleoside-diphosphate reductase subunit M2

    See identical proteins and their annotated locations for NP_033130.1

    Status: VALIDATED

    Source sequence(s)
    BC085136, BF468116
    Consensus CDS
    CCDS25844.1
    UniProtKB/Swiss-Prot
    P11157, Q3UI23, Q542E2
    UniProtKB/TrEMBL
    Q3THV8
    Related
    ENSMUSP00000020980.6, ENSMUST00000020980.12
    Conserved Domains (1) summary
    PLN02492
    Location:71390
    PLN02492; ribonucleoside-diphosphate reductase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    24758253..24764145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)